PMID- 2031665
OWN - NLM
STAT- MEDLINE
DCOM- 19910621
LR  - 20191029
IS  - 0896-8411 (Print)
IS  - 0896-8411 (Linking)
VI  - 4
IP  - 1
DP  - 1991 Feb
TI  - Subacute cutaneous lupus erythematosus-immunogenetic associations.
PG  - 73-85
AB  - Thirty-two patients who fulfilled criteria for subacute cutaneous lupus 
      erythematosus (SCLE) were examined for their immunogenetic associations. Our 
      results confirm the previously reported association of HLA-DR3 (15/31 48% P less 
      than 0.01) and also demonstrate an increase in HLA-DR2 (14/31, 45%, P = less than 
      0.05). These findings indicate there are two distinct immunogenetic (HLA) 
      populations of Ro(SS-A) antibody-positive SCLE patients. The increased frequency 
      of HLA-DR2 and DR3 appears to be associated with expression of the Ro(SS-A) 
      antibody, since no HLA associations were seen in Ro(SS-A)-negative SCLE patients 
      when compared with normal population controls. Furthermore, these data indicate 
      that the distinctive cutaneous lesions of SCLE are not associated with one 
      specific HLA allele, as previously suspected. These findings contrast with the 
      relatively homogeneous immunogenetic background seen in other lupus erythematosus 
      subsets with a high frequency of Ro(SS-A) antibody, i.e., neonatal lupus 
      erythematosus and Sjogren's syndrome/lupus erythematosus overlap (increased 
      frequency of HLA-DR3, DQw2 and DRW52).
FAU - Watson, R M
AU  - Watson RM
AD  - Department of Dermatology, Johns Hopkins Hospital, Baltimore, Maryland.
FAU - Talwar, P
AU  - Talwar P
FAU - Alexander, E
AU  - Alexander E
FAU - Bias, W B
AU  - Bias WB
FAU - Provost, T T
AU  - Provost TT
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - England
TA  - J Autoimmun
JT  - Journal of autoimmunity
JID - 8812164
RN  - 0 (Antibodies, Antinuclear)
RN  - 0 (HLA-DR2 Antigen)
RN  - 0 (HLA-DR3 Antigen)
RN  - 0 (SS-A antibodies)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Antibodies, Antinuclear/genetics
MH  - Female
MH  - Gene Frequency
MH  - HLA-DR2 Antigen/genetics
MH  - HLA-DR3 Antigen/genetics
MH  - Humans
MH  - Immunogenetics
MH  - Infant, Newborn
MH  - Lupus Erythematosus, Cutaneous/genetics/*immunology
MH  - Lupus Erythematosus, Systemic/genetics/immunology
MH  - Male
MH  - Middle Aged
MH  - Sjogren's Syndrome/genetics/immunology
EDAT- 1991/02/01 00:00
MHDA- 1991/02/01 00:01
CRDT- 1991/02/01 00:00
PHST- 1991/02/01 00:00 [pubmed]
PHST- 1991/02/01 00:01 [medline]
PHST- 1991/02/01 00:00 [entrez]
AID - 0896-8411(91)90008-Z [pii]
AID - 10.1016/0896-8411(91)90008-z [doi]
PST - ppublish
SO  - J Autoimmun. 1991 Feb;4(1):73-85. doi: 10.1016/0896-8411(91)90008-z.