PMID- 20332300
OWN - NLM
STAT- MEDLINE
DCOM- 20100625
LR  - 20151119
IS  - 1940-6215 (Electronic)
IS  - 1940-6215 (Linking)
VI  - 3
IP  - 4
DP  - 2010 Apr
TI  - Lung cancer biomarkers: FISHing in the sputum for risk assessment and early 
      detection.
PG  - 420-3
LID - 10.1158/1940-6207.CAPR-10-0052 [doi]
AB  - This perspective on Varella-Garcia et al. (beginning on p. 447 in this issue of 
      the journal) discusses the role of sputum-based biomarkers in the risk assessment 
      and early detection of lung cancer. The importance of the detection of sputum 
      epithelial chromosomal aneusomy by fluorescence in situ hybridization (FISH) as a 
      potential risk or early-detection biomarker is discussed in the context of other 
      biomarkers and models in lung carcinogenesis. The presently reported findings on 
      FISH in sputum cells are an important contribution worthy of further 
      investigation in defined clinical settings.
CI  - (c) 2010 AACR.
FAU - Gomperts, Brigitte N
AU  - Gomperts BN
AD  - David Geffen School of Medicine, University of California at Los Angeles, 10833 
      Le Conte Avenue, Los Angeles, CA 90095, USA. bgomperts@mednet.ucla.edu
FAU - Spira, Avrum
AU  - Spira A
FAU - Elashoff, David E
AU  - Elashoff DE
FAU - Dubinett, Steven M
AU  - Dubinett SM
LA  - eng
PT  - Comment
PT  - Journal Article
PT  - Review
DEP - 20100323
PL  - United States
TA  - Cancer Prev Res (Phila)
JT  - Cancer prevention research (Philadelphia, Pa.)
JID - 101479409
RN  - 0 (Biomarkers, Tumor)
SB  - IM
CON - Cancer Prev Res (Phila). 2010 Apr;3(4):447-53. PMID: 20332298
MH  - Biomarkers, Tumor/*analysis/genetics
MH  - Early Detection of Cancer/*methods
MH  - Humans
MH  - *In Situ Hybridization, Fluorescence
MH  - Lung Neoplasms/*diagnosis/genetics
MH  - Risk Assessment
MH  - Sputum/*cytology
RF  - 37
EDAT- 2010/03/25 06:00
MHDA- 2010/06/26 06:00
CRDT- 2010/03/25 06:00
PHST- 2010/03/25 06:00 [entrez]
PHST- 2010/03/25 06:00 [pubmed]
PHST- 2010/06/26 06:00 [medline]
AID - 1940-6207.CAPR-10-0052 [pii]
AID - 10.1158/1940-6207.CAPR-10-0052 [doi]
PST - ppublish
SO  - Cancer Prev Res (Phila). 2010 Apr;3(4):420-3. doi: 
      10.1158/1940-6207.CAPR-10-0052. Epub 2010 Mar 23.