PMID- 20332716
OWN - NLM
STAT- MEDLINE
DCOM- 20100713
LR  - 20170306
VI  - 120
IP  - 3
DP  - 2010 Mar
TI  - Which patients with chronic heart failure should be referred for CRT-D 
      implantation? Practical implications of current clinical research.
PG  - 95-102
LID - 455 [pii]
AB  - Over the last decade, cardiac resynchronization therapy (CRT) has emerged as an 
      important treatment modality in patients with heart failure. Primary prevention 
      of mortality with implantable cardioverter-defibrillator (ICD) in patients with 
      ischemic and nonischemic cardiomyopathy and left ventricular dysfunction 
      (ejection fraction [EF] < or =35%) has become the standard of care. A growing 
      number of patients with indications for ICD are also eligible for CRT, receiving 
      resynchronization pacing-defibrillator devices (CRT-D). Randomized clinical 
      trials have provided evidence that cardiac resynchronization therapy is 
      beneficial in heart failure patients and contributes to a significant decrease in 
      heart failure progression on top of administering optimal pharmacological 
      therapy. Currently approved indications for CRT-D include utilizing this 
      treatment modality in heart failure patients with New York Heart Association 
      (NYHA) class III or IV, EF < or =35%, and QRS > or =120 ms. New data from 
      MADIT-CRT (Multicenter Automatic Defibrillator Implantation Trial-Cardiac 
      Resynchronization Therapy) document that patients with less advanced heart 
      failure (ischemic cardiomyopathy in NYHA class I or II and nonischemic 
      cardiomyopathy class II), EF < or =30%, and QRS > or =130 ms also benefit from 
      CRT. These findings indicate that a more proactive approach should be considered 
      regarding the management of heart failure patients with less advanced disease to 
      decrease progression of heart failure with CRT-D therapy.
FAU - Zareba, Wojciech
AU  - Zareba W
AD  - Cardiology Division, University of Rochester Medical Center, Rochester, New York, 
      USA. wojciech_zareba@urmc.rochester.edu
FAU - Zareba, Karolina M
AU  - Zareba KM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - Poland
TA  - Pol Arch Med Wewn
JT  - Polskie Archiwum Medycyny Wewnetrznej
JID - 0401225
SB  - IM
MH  - *Cardiac Pacing, Artificial
MH  - *Defibrillators, Implantable
MH  - Heart Failure/*therapy
MH  - Humans
MH  - *Pacemaker, Artificial
MH  - Referral and Consultation
MH  - Severity of Illness Index
RF  - 25
EDAT- 2010/03/25 06:00
MHDA- 2010/07/14 06:00
CRDT- 2010/03/25 06:00
PHST- 2010/03/25 06:00 [entrez]
PHST- 2010/03/25 06:00 [pubmed]
PHST- 2010/07/14 06:00 [medline]
AID - 455 [pii]
PST - ppublish
SO  - Pol Arch Med Wewn. 2010 Mar;120(3):95-102.