PMID- 20334725
OWN - NLM
STAT- MEDLINE
DCOM- 20110318
LR  - 20161020
IS  - 1469-5111 (Electronic)
IS  - 1461-1457 (Linking)
VI  - 13
IP  - 10
DP  - 2010 Nov
TI  - Drug seeking in response to a priming injection of MDMA in rats: relationship to 
      initial sensitivity to self-administered MDMA and dorsal striatal dopamine.
PG  - 1315-27
LID - 10.1017/S1461145710000283 [doi]
AB  - In laboratory animals, exposure to priming injections of 
      3,4-methylenedioxymethamphetamine (MDMA) produced drug seeking following 
      extinction of MDMA self-administration. This study aimed to evaluate whether the 
      magnitude of drug seeking was related to latency to acquisition of MDMA 
      self-administration and increases in striatal dopamine, as measured by in-vivo 
      microdialysis. Rats were given daily access to MDMA self-administration until 
      they earned a total of 240 infusions (total intake of 165 mg/kg MDMA). Twelve of 
      the 20 rats acquired self-administration within the temporal limits of the study 
      and the latency to meet the criterion ranged from 9 d to 37 d. An 
      experimenter-administered injection of MDMA (10.0 mg/kg i.p.) produced drug 
      seeking in these rats, and the number of responses was significantly higher than 
      responses produced by rats that failed to meet the criterion or by yoked control 
      rats that received the drug passively. For rats that met the criterion, drug 
      seeking was negatively correlated with the number of days to self-administer the 
      criterion number of MDMA infusions and positively correlated with MDMA-produced 
      dopamine in the dorsal striatum. Importantly, MDMA-produced dopamine overflow was 
      greater for the rats that met the criterion. These findings suggest that drug 
      seeking is influenced by initial sensitivity to the reinforcing effects of MDMA 
      and to drug-produced increases in striatal dopamine.
FAU - Colussi-Mas, Joyce
AU  - Colussi-Mas J
AD  - Victoria University of Wellington, School of Psychology, Wellington, New Zealand.
FAU - Wise, Richard J
AU  - Wise RJ
FAU - Howard, Alex
AU  - Howard A
FAU - Schenk, Susan
AU  - Schenk S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100325
PL  - England
TA  - Int J Neuropsychopharmacol
JT  - The international journal of neuropsychopharmacology
JID - 9815893
RN  - 0 (Dopamine Agents)
RN  - 0 (Serotonin Agents)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
RN  - VTD58H1Z2X (Dopamine)
SB  - IM
MH  - Animals
MH  - Behavior, Animal/drug effects
MH  - Corpus Striatum/drug effects
MH  - Dopamine/analysis/pharmacology
MH  - Dopamine Agents/analysis/pharmacology
MH  - Drug-Seeking Behavior/*drug effects
MH  - Injections
MH  - Male
MH  - Microdialysis
MH  - Models, Animal
MH  - N-Methyl-3,4-methylenedioxyamphetamine/administration & 
      dosage/metabolism/*pharmacology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Self Administration
MH  - Serotonin Agents/*administration & dosage/metabolism/*pharmacology
EDAT- 2010/03/26 06:00
MHDA- 2011/03/19 06:00
CRDT- 2010/03/26 06:00
PHST- 2010/03/26 06:00 [entrez]
PHST- 2010/03/26 06:00 [pubmed]
PHST- 2011/03/19 06:00 [medline]
AID - S1461145710000283 [pii]
AID - 10.1017/S1461145710000283 [doi]
PST - ppublish
SO  - Int J Neuropsychopharmacol. 2010 Nov;13(10):1315-27. doi: 
      10.1017/S1461145710000283. Epub 2010 Mar 25.