PMID- 20335354
OWN - NLM
STAT- MEDLINE
DCOM- 20110621
LR  - 20211020
IS  - 1879-0844 (Electronic)
IS  - 1388-9842 (Print)
IS  - 1388-9842 (Linking)
VI  - 12
IP  - 4
DP  - 2010 Apr
TI  - Effectiveness of cardiac resynchronization therapy in mild congestive heart 
      failure: systematic review and meta-analysis of randomized trials.
PG  - 360-6
LID - 10.1093/eurjhf/hfq029 [doi]
AB  - AIMS: Cardiac resynchronization therapy (CRT) improves echocardiographic 
      parameters, symptoms, hospitalizations, and mortality in patients with New York 
      Heart Association (NYHA) Class III or IV symptoms with left ventricular systolic 
      dysfunction, sinus rhythm, and a prolonged QRS duration. The effectiveness of CRT 
      in patients with mild heart failure symptoms has not been systematically 
      reviewed. METHODS AND RESULTS: Randomized controlled trials of CRT in patients 
      with NYHA Class I or II heart failure were identified from MEDLINE and EMBASE. 
      The effects of CRT on left ventricular remodelling at 1 year were systematically 
      reviewed, and the effects of CRT on clinical outcomes at 1 year were 
      meta-analysed. Two studies met the pre-specified search criteria, with a total of 
      2430 patients (REVERSE n = 610 and MADIT-CRT n = 1820). CRT was associated with a 
      reduction in heart failure events in both trials [combined OR 0.57, 95% 
      confidence interval (CI) 0.46-0.70], but not mortality (combined OR 0.96, 95% CI 
      0.67-1.36). The effect of CRT on the combined endpoint of heart failure events or 
      death favoured CRT (OR 0.63, 95% CI 0.51-0.77). CRT was also associated with 
      improvement in left ventricular remodelling parameters in both studies, including 
      a greater increase in left ventricular ejection fraction in the CRT group than in 
      the control group, at 1 year after randomization. Serious adverse events were 
      rare with CRT. CONCLUSION: CRT reduces heart failure events in patients with mild 
      heart failure symptoms, left ventricular dysfunction, sinus rhythm, and prolonged 
      QRS duration.
FAU - Lubitz, Steven A
AU  - Lubitz SA
AD  - Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA.
FAU - Leong-Sit, Peter
AU  - Leong-Sit P
FAU - Fine, Nowell
AU  - Fine N
FAU - Kramer, Daniel B
AU  - Kramer DB
FAU - Singh, Jagmeet
AU  - Singh J
FAU - Ellinor, Patrick T
AU  - Ellinor PT
LA  - eng
GR  - R21 DA027021/DA/NIDA NIH HHS/United States
GR  - K24 HL105780/HL/NHLBI NIH HHS/United States
GR  - R01 HL104156/HL/NHLBI NIH HHS/United States
GR  - HL092577/HL/NHLBI NIH HHS/United States
GR  - DA027021/DA/NIDA NIH HHS/United States
GR  - T32HL007575/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Meta-Analysis
PT  - Research Support, N.I.H., Extramural
PT  - Review
PT  - Systematic Review
PL  - England
TA  - Eur J Heart Fail
JT  - European journal of heart failure
JID - 100887595
SB  - IM
MH  - Aged
MH  - *Cardiac Resynchronization Therapy
MH  - Confidence Intervals
MH  - Female
MH  - Heart Failure/mortality/*therapy
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Odds Ratio
MH  - Randomized Controlled Trials as Topic
MH  - Severity of Illness Index
MH  - United States
MH  - Ventricular Dysfunction, Left/therapy
MH  - Ventricular Remodeling
PMC - PMC2844759
EDAT- 2010/03/26 06:00
MHDA- 2011/06/22 06:00
PMCR- 2011/04/01
CRDT- 2010/03/26 06:00
PHST- 2010/03/26 06:00 [entrez]
PHST- 2010/03/26 06:00 [pubmed]
PHST- 2011/06/22 06:00 [medline]
PHST- 2011/04/01 00:00 [pmc-release]
AID - hfq029 [pii]
AID - 10.1093/eurjhf/hfq029 [doi]
PST - ppublish
SO  - Eur J Heart Fail. 2010 Apr;12(4):360-6. doi: 10.1093/eurjhf/hfq029.