PMID- 20335631
OWN - NLM
STAT- MEDLINE
DCOM- 20100504
LR  - 20230216
IS  - 1541-6100 (Electronic)
IS  - 0022-3166 (Linking)
VI  - 140
IP  - 5
DP  - 2010 May
TI  - Postprandial nutrient partitioning but not energy expenditure is modified in 
      growing rats during adaptation to a high-protein diet.
PG  - 939-45
LID - 10.3945/jn.109.120139 [doi]
AB  - It has been suggested that high-protein (HP) diets may favor weight management by 
      lowering energy intake and reducing body fat. Whether these effects result from 
      changes in energy metabolism remains unclear. We measured the adaptation of 
      energy metabolism components during 2 wk of HP feeding. Fifty male Wistar rats 
      were switched from a control diet to an HP diet (14 and 55% of protein, 
      respectively) for 1, 3, 6, or 14 d. Energy expenditure (EE) and substrate 
      oxidation were measured by indirect calorimetry in feed-deprived rats and after 
      consumption of a test meal. EE components, including the thermic effect of 
      feeding and activity, were not modified during adaptation to an HP diet. Nutrient 
      oxidation in feed-deprived rats was not affected by HP feeding, except for an 
      early increase in protein oxidation. After 1 d, the postprandial inhibition of 
      lipid oxidation (Lox) was blunted, carbohydrate (CHO) oxidation decreased by 
      one-half, and urea clearance decreased by 66%. Thereafter, CHO oxidation 
      gradually rose, resulting in a null CHO balance. Lox and urea clearance recovered 
      after 3 d of adaptation to an HP diet, while protein oxidation reached a plateau. 
      The postprandial oxidation of CHO counterbalanced the amount of ingested CHO as 
      soon as 3 d, leading to a null postprandial CHO balance. We conclude that the 
      inhibition of de novo lipogenesis from dietary CHO, but not EE and Lox, may 
      participate in limiting the adiposity induced by HP feeding. The transient 
      changes occurring during the period of adaptation to the diet highlight that the 
      duration of the diet is critical in HP diet studies.
FAU - Stepien, Magdalena
AU  - Stepien M
AD  - INRA, AgroParisTech, UMR914 Nutrition Physiology and Ingestive Behavior, F-75005 
      Paris, France.
FAU - Gaudichon, Claire
AU  - Gaudichon C
FAU - Azzout-Marniche, Dalila
AU  - Azzout-Marniche D
FAU - Fromentin, Gilles
AU  - Fromentin G
FAU - Tome, Daniel
AU  - Tome D
FAU - Even, Patrick
AU  - Even P
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100324
PL  - United States
TA  - J Nutr
JT  - The Journal of nutrition
JID - 0404243
RN  - 0 (Dietary Carbohydrates)
RN  - 0 (Dietary Fats)
RN  - 0 (Dietary Proteins)
RN  - 8W8T17847W (Urea)
SB  - IM
MH  - Adiposity/*physiology
MH  - Animals
MH  - Body Temperature Regulation
MH  - Calorimetry, Indirect
MH  - Dietary Carbohydrates/administration & dosage/*metabolism
MH  - Dietary Fats/administration & dosage/*metabolism
MH  - Dietary Proteins/administration & dosage/*metabolism
MH  - *Energy Metabolism
MH  - Lipogenesis/*physiology
MH  - Male
MH  - Obesity/*metabolism
MH  - Oxidation-Reduction
MH  - Postprandial Period
MH  - Rats
MH  - Rats, Wistar
MH  - Urea/metabolism
EDAT- 2010/03/26 06:00
MHDA- 2010/05/05 06:00
CRDT- 2010/03/26 06:00
PHST- 2010/03/26 06:00 [entrez]
PHST- 2010/03/26 06:00 [pubmed]
PHST- 2010/05/05 06:00 [medline]
AID - S0022-3166(22)07053-5 [pii]
AID - 10.3945/jn.109.120139 [doi]
PST - ppublish
SO  - J Nutr. 2010 May;140(5):939-45. doi: 10.3945/jn.109.120139. Epub 2010 Mar 24.