PMID- 20337940
OWN - NLM
STAT- MEDLINE
DCOM- 20110926
LR  - 20140730
IS  - 1439-0507 (Electronic)
IS  - 0933-7407 (Linking)
VI  - 54
IP  - 4
DP  - 2011 Jul
TI  - Immune reconstitution inflammatory syndrome (IRIS) associated with Cryptococcus 
      neoformans infection in AIDS patients.
PG  - e178-82
LID - 10.1111/j.1439-0507.2010.01870.x [doi]
AB  - Cryptococcosis is frequently associated to the immune reconstitution inflammatory 
      syndrome (IRIS) in AIDS patients on highly active antiretroviral therapy (HAART). 
      This study aimed to evaluate clinical and evolutive features of IRIS associated 
      cryptococcosis patients in Uberaba, Brazil. PATIENTS: Eighty-one AIDS individuals 
      admitted at the teaching hospital with cryptococcal meningitis were evaluated and 
      from these, 40 were prospectively followed. Of 40 patients with cryptococcosis, 
      nine (22.5%) presented clinical and laboratory features of IRIS. Six (66.6%) were 
      male, with a mean age of 37.2. Five (55.5%) presented cryptococcosis as first 
      AIDS defining condition. In seven (77.9%) IRIS was characterised as a relapse of 
      meningeal symptoms after 10 weeks, mean time of 72 days, of starting HAART 
      whereas, two asymptomatic patients developed the syndrome as an unmasked 
      cryptococcosis after 10 and 12 weeks on HAART. Lymphadenitis as isolated finding 
      associated with IRIS was evidenced in three cases. All patients presented low 
      CD4(+) and high RNA viral load baseline values. Cultures of cerebrospinal fluid 
      and lymph-node fragments tissues of these cases were negative. Six of nine 
      individuals developed high intracranial pressure requiring a daily relief lumbar 
      puncture. No deaths occurred during the evolution of these patients. The 
      incidence and clinical evolutive profile observed in this case series are in 
      accordance with other reports elsewhere.
CI  - (c) 2010 Blackwell Verlag GmbH.
FAU - da Cunha Colombo, Eduardo Rodrigues
AU  - da Cunha Colombo ER
AD  - Department of Infectious Diseases. Universidade Federal do Triangulo Mineiro, 
      Uberaba, Minas Gerais, Brazil.
FAU - Mora, Delio Jose
AU  - Mora DJ
FAU - Silva-Vergara, Mario Leon
AU  - Silva-Vergara ML
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100322
PL  - Germany
TA  - Mycoses
JT  - Mycoses
JID - 8805008
RN  - 0 (Anti-HIV Agents)
SB  - IM
MH  - Acquired Immunodeficiency Syndrome/*complications/*drug therapy
MH  - Adult
MH  - Anti-HIV Agents/*administration & dosage
MH  - Brazil/epidemiology
MH  - Cryptococcosis/*epidemiology/immunology/*pathology
MH  - Cryptococcus neoformans/*isolation & purification
MH  - Female
MH  - Follow-Up Studies
MH  - Hospitals, Teaching
MH  - Humans
MH  - Immune Reconstitution Inflammatory Syndrome/*pathology
MH  - Incidence
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
EDAT- 2010/03/27 06:00
MHDA- 2011/09/29 06:00
CRDT- 2010/03/27 06:00
PHST- 2010/03/27 06:00 [entrez]
PHST- 2010/03/27 06:00 [pubmed]
PHST- 2011/09/29 06:00 [medline]
AID - MYC1870 [pii]
AID - 10.1111/j.1439-0507.2010.01870.x [doi]
PST - ppublish
SO  - Mycoses. 2011 Jul;54(4):e178-82. doi: 10.1111/j.1439-0507.2010.01870.x. Epub 2010 
      Mar 22.