PMID- 20337972
OWN - NLM
STAT- MEDLINE
DCOM- 20110311
LR  - 20221207
IS  - 1399-5448 (Electronic)
IS  - 1399-543X (Linking)
VI  - 11
IP  - 8
DP  - 2010 Dec
TI  - An observational study of type 2 diabetes within a large Australian tertiary 
      hospital pediatric diabetes service.
PG  - 544-51
LID - 10.1111/j.1399-5448.2010.00647.x [doi]
AB  - BACKGROUND: Type 2 diabetes mellitus (T2DM) is emerging as a significant clinical 
      problem within the pediatric population. OBJECTIVE: The objective of this study 
      was to identify patients with T2DM in a large tertiary hospital diabetes service 
      and examine aspects relating to clinical course and management. METHODS: An 
      initial audit of our diabetes service (over 6 yr) was followed by a 2-yr period 
      of prospective case ascertainment to identify patients with T2DM. Comprehensive 
      data collection was then undertaken in these individuals. RESULTS: Within our 
      service (n = 1574), 33 young people with T2DM were identified. Significant levels 
      of co-morbidity were evident - dyslipidaemia (56%), microalbuminuria (45%), 
      hypertension (30%) and abnormal retinal findings (25%). Hypertension was more 
      likely in those with greater initial and follow-up body mass index (BMI) [mean 
      (SD) BMI: 36.3 (5.0) vs. 28.0 (6.3) kg/m(2) , p = 0.001, and 36.8 (5.3) vs. 28.5 
      (7.8) kg/m(2) , p = 0.007, respectively] and BMI standard deviation score (SDS) 
      [mean (SD) BMI SDS: 2.34 (0.30) vs. 1.72 (0.66), p = 0.001, and 2.26 (0.31) vs. 
      1.38 (0.87), p < 0.001, respectively], whereas abnormal retinal findings were 
      seen in those with higher HbA1c values at last appointment [geometric mean 
      (range) 10.9 (8.4-13.6) vs. 7.4 (5.6-12.5)%, p = 0.01) and those with greater 
      increases in HbA1c over time (+4.1 (3.1) vs. +0.2 (1.9)%, p = 0.009). Of the 33,9 
      (27%) were lost to follow-up. CONCLUSIONS: At present, T2DM in youth remains a 
      low burden on our services. Patients with this diagnosis, however, have 
      significant problems that present a major challenge to the development of 
      effective management strategies.
CI  - (c) 2010 John Wiley & Sons A/S.
FAU - Ruhayel, Sandra D
AU  - Ruhayel SD
AD  - Department of Endocrinology and Diabetes at the Royal Children's Hospital, 
      Parkville, Victoria, Australia.
FAU - James, Rebecca A
AU  - James RA
FAU - Ehtisham, Sarah
AU  - Ehtisham S
FAU - Cameron, Fergus J
AU  - Cameron FJ
FAU - Werther, George A
AU  - Werther GA
FAU - Sabin, Matthew A
AU  - Sabin MA
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Denmark
TA  - Pediatr Diabetes
JT  - Pediatric diabetes
JID - 100939345
RN  - 0 (Glycated Hemoglobin A)
RN  - 0 (hemoglobin A1c protein, human)
SB  - IM
MH  - Adolescent
MH  - Albuminuria/etiology
MH  - Australia/epidemiology
MH  - Body Mass Index
MH  - Child
MH  - Diabetes Mellitus, Type 2/complications/*epidemiology/therapy
MH  - Dyslipidemias/etiology
MH  - Female
MH  - Glycated Hemoglobin/metabolism
MH  - Hospitals, Pediatric
MH  - Humans
MH  - Hypertension/complications
MH  - Male
EDAT- 2010/03/27 06:00
MHDA- 2011/03/12 06:00
CRDT- 2010/03/27 06:00
PHST- 2010/03/27 06:00 [entrez]
PHST- 2010/03/27 06:00 [pubmed]
PHST- 2011/03/12 06:00 [medline]
AID - PDI647 [pii]
AID - 10.1111/j.1399-5448.2010.00647.x [doi]
PST - ppublish
SO  - Pediatr Diabetes. 2010 Dec;11(8):544-51. doi: 10.1111/j.1399-5448.2010.00647.x.