PMID- 20337975
OWN - NLM
STAT- MEDLINE
DCOM- 20110311
LR  - 20211020
IS  - 1399-5448 (Electronic)
IS  - 1399-543X (Linking)
VI  - 11
IP  - 8
DP  - 2010 Dec
TI  - Type 1 diabetes patients born to immigrants to Sweden increase their native 
      diabetes risk and differ from Swedish patients in HLA types and islet 
      autoantibodies.
PG  - 513-20
LID - 10.1111/j.1399-5448.2010.00637.x [doi]
AB  - AIM: To determine whether type 1 diabetes mellitus (T1DM) patients, having 
      parents who immigrated to Sweden, have increased T1DM risk before 18 yr compared 
      with countries of origin. We also determined whether they have different human 
      leukocyte antigen (HLA) genetic markers and islet autoantibodies at diagnosis 
      compared with Swedish patients. METHODS: A total of 1988 (53% males) newly 
      diagnosed and confirmed T1DM patients <18 yr registered within the Better 
      Diabetes Diagnosis (BDD) study (May 2005 to September 2008) were included. 
      Participants were classified into three groups: Swedish, non-Swedish, and 
      Mixed-origin patients according to country of origin of two generations (parents 
      and grandparents). These groups were compared with respect to T1DM HLA markers 
      and islet autoantibodies [glutamic acid decarboxylase autoantibodies (GAD65Ab), 
      insulin autoantibodies (IAA), and islet antigen-2 autoantibodies (IA-2Ab)]. 
      RESULTS: Only 30 (1.5%) patients were born outside Sweden. Swedish patients 
      constituted 66%, non-Swedish patients 8%, Mixed origins 17%, and 9% were of 
      uncertain origin. Confirmed T1DM in patients within the study was 22 (95% CI: 
      21-23) patients/10(5)/yr rate for Swedish patients compared with 14 (95% CI: 
      13-15) among non-Swedish patients. The HLA-DQ8 haplotype (p < 0.0001) and DQ2/8 
      genotype (p < 0.02) predominated among Swedish compared with non-Swedish 
      patients. In contrast, DQ2 was the most frequent haplotype among non-Swedish 
      patients [OR = 1.5 (95% CI: 1.0-2.0), p < 0.04]. Multiple (>/=2) autoantibodies (p 
      < 0.04) and specifically IA-2Ab (p < 0.001) were most prevalent among the Swedish 
      patients. Multiple autoantibodies were associated with DQ8 among the Swedish 
      patients only (p < 0.001). CONCLUSION: Patients born to parents who had 
      immigrated to the high T1DM incidence environment of Sweden have, compared with 
      Swedish patients, more frequent HLA-DQ2 genetic markers and are diagnosed more 
      often with GAD65Ab.
CI  - (c) 2010 John Wiley & Sons A/S.
FAU - Delli, Ahmed J
AU  - Delli AJ
AD  - Department of Clinical Sciences, Lund University, Malmo, Sweden. 
      ahmed.delli@med.lu.se
FAU - Lindblad, Bengt
AU  - Lindblad B
FAU - Carlsson, Annelie
AU  - Carlsson A
FAU - Forsander, Gun
AU  - Forsander G
FAU - Ivarsson, Sten-A
AU  - Ivarsson SA
FAU - Ludvigsson, Johnny
AU  - Ludvigsson J
FAU - Marcus, Claude
AU  - Marcus C
FAU - Lernmark, Ake
AU  - Lernmark A
CN  - Better Diabetes Diagnosis (BDD) Study Group
LA  - eng
GR  - R01 DK026190/DK/NIDDK NIH HHS/United States
GR  - DK63861/DK/NIDDK NIH HHS/United States
GR  - DK26190/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - Denmark
TA  - Pediatr Diabetes
JT  - Pediatric diabetes
JID - 100939345
RN  - 0 (Autoantibodies)
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DQ2 antigen)
RN  - 0 (HLA-DQ8 antigen)
RN  - EC 4.1.1.15 (Glutamate Decarboxylase)
SB  - IM
CIN - Pediatr Diabetes. 2010 Dec;11(8):511-2. PMID: 21118341
MH  - Adolescent
MH  - Autoantibodies/analysis/genetics
MH  - Child
MH  - Child, Preschool
MH  - Cohort Studies
MH  - Diabetes Mellitus, Type 1/*epidemiology/genetics/*immunology
MH  - Emigrants and Immigrants
MH  - Female
MH  - Glutamate Decarboxylase/genetics/immunology
MH  - HLA-DQ Antigens/genetics/immunology
MH  - Humans
MH  - Infant
MH  - Islets of Langerhans/immunology
MH  - Male
MH  - Sweden/epidemiology
FIR - Samuelsson, Bengt-Olof
IR  - Samuelsson BO
FIR - Snellman, Kalle
IR  - Snellman K
FIR - Olivecrona, Anna
IR  - Olivecrona A
FIR - Stenberg, Ake
IR  - Stenberg A
FIR - Skogsberg, Lars
IR  - Skogsberg L
FIR - Lindblad, Bengt
IR  - Lindblad B
FIR - Forsander, Gun
IR  - Forsander G
FIR - Nilsson, Nils Osten
IR  - Nilsson NO
FIR - Neiderud, Jan
IR  - Neiderud J
FIR - Torbjornsdotter, Torun
IR  - Torbjornsdotter T
FIR - Hagg, Thomas
IR  - Hagg T
FIR - Hemmingsson, Kristina
IR  - Hemmingsson K
FIR - Akesson, Karin
IR  - Akesson K
FIR - Lundstrom, Goran
IR  - Lundstrom G
FIR - Ljungcrantz, Magnus
IR  - Ljungcrantz M
FIR - Forssberg, Maria
IR  - Forssberg M
FIR - Larsson, Karin
IR  - Larsson K
FIR - Gundewall, Christer
IR  - Gundewall C
FIR - Enander, Rebecka
IR  - Enander R
FIR - Samuelsson, Ulf
IR  - Samuelsson U
FIR - Carlsson, Annelie
IR  - Carlsson A
FIR - Nilsson, Anita
IR  - Nilsson A
FIR - Larsson, Helena E
IR  - Larsson HE
FIR - Ivarsson, Sten-A
IR  - Ivarsson SA
FIR - Brannstrom, Agneta
IR  - Brannstrom A
FIR - Nordwall, Maria
IR  - Nordwall M
FIR - Hellenberg, Lennart
IR  - Hellenberg L
FIR - Lundberg, Elena
IR  - Lundberg E
FIR - Tollig, Henrik
IR  - Tollig H
FIR - Bjorsell, Britta
IR  - Bjorsell B
FIR - Ortqvist, Eva
IR  - Ortqvist E
FIR - Kernell, Anna
IR  - Kernell A
FIR - Stjernstedt, Bjorn
IR  - Stjernstedt B
FIR - Wramner, Nils
IR  - Wramner N
FIR - Hanas, Ragnar
IR  - Hanas R
FIR - Swenne, Ingemar
IR  - Swenne I
FIR - Blomgren, Margareta
IR  - Blomgren M
FIR - Thastrom, Anders
IR  - Thastrom A
FIR - Arvidsson, C G
IR  - Arvidsson CG
FIR - Edvardsson, Stig
IR  - Edvardsson S
FIR - Jonsson, Bjorn
IR  - Jonsson B
FIR - Gadd, Torsten
IR  - Gadd T
FIR - Aman, Jan
IR  - Aman J
FIR - Florell, Rein
IR  - Florell R
FIR - Fureman, Anna-Lena
IR  - Fureman AL
EDAT- 2010/03/27 06:00
MHDA- 2011/03/12 06:00
CRDT- 2010/03/27 06:00
PHST- 2010/03/27 06:00 [entrez]
PHST- 2010/03/27 06:00 [pubmed]
PHST- 2011/03/12 06:00 [medline]
AID - PDI637 [pii]
AID - 10.1111/j.1399-5448.2010.00637.x [doi]
PST - ppublish
SO  - Pediatr Diabetes. 2010 Dec;11(8):513-20. doi: 10.1111/j.1399-5448.2010.00637.x.