PMID- 20338194
OWN - NLM
STAT- MEDLINE
DCOM- 20100913
LR  - 20171116
IS  - 1879-0003 (Electronic)
IS  - 0141-8130 (Linking)
VI  - 46
IP  - 5
DP  - 2010 Jun
TI  - Effect of 2-hydroxypropyl-beta-cyclodextrin on thermal inactivation, denaturation 
      and aggregation of glyceraldehyde-3-phosphate dehydrogenase from rabbit skeletal 
      muscle.
PG  - 487-92
LID - 10.1016/j.ijbiomac.2010.03.008 [doi]
AB  - The effect of 2-hydroxypropyl-beta-cyclodextrin (HP-beta-CD) on thermal 
      aggregation of glyceraldehyde-3-phosphate dehydrogenase (GAPDH) from rabbit 
      skeletal muscle at 45 degrees C has been studied using dynamic light scattering. 
      In the presence of HP-beta-CD higher values of the rate of aggregation and larger 
      aggregates were registered. The acceleration of GAPDH aggregation was due to 
      destabilization of the enzyme molecule under the action of HP-beta-CD. This is 
      evidenced by the data on thermal inactivation of GAPDH and differential scanning 
      calorimetry.
CI  - Copyright 2010 Elsevier B.V. All rights reserved.
FAU - Maloletkina, Olga I
AU  - Maloletkina OI
AD  - Bach Institute of Biochemistry, Russian Academy of Sciences, Leninsky Pr. 33, 
      119071, Moscow, Russia.
FAU - Markossian, Kira A
AU  - Markossian KA
FAU - Asryants, Regina A
AU  - Asryants RA
FAU - Semenyuk, Pavel I
AU  - Semenyuk PI
FAU - Makeeva, Valentina F
AU  - Makeeva VF
FAU - Kurganov, Boris I
AU  - Kurganov BI
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100323
PL  - Netherlands
TA  - Int J Biol Macromol
JT  - International journal of biological macromolecules
JID - 7909578
RN  - 0 (beta-Cyclodextrins)
RN  - 1I96OHX6EK (2-Hydroxypropyl-beta-cyclodextrin)
RN  - EC 1.2.1.- (Glyceraldehyde-3-Phosphate Dehydrogenases)
SB  - IM
MH  - 2-Hydroxypropyl-beta-cyclodextrin
MH  - Animals
MH  - Enzyme Activation/drug effects
MH  - Glyceraldehyde-3-Phosphate Dehydrogenases/*chemistry/*metabolism
MH  - Muscle, Skeletal/*drug effects/*enzymology
MH  - Protein Denaturation/drug effects
MH  - Protein Structure, Quaternary
MH  - Rabbits
MH  - Refractometry
MH  - *Temperature
MH  - Viscosity/drug effects
MH  - beta-Cyclodextrins/*pharmacology
EDAT- 2010/03/27 06:00
MHDA- 2010/09/14 06:00
CRDT- 2010/03/27 06:00
PHST- 2010/01/21 00:00 [received]
PHST- 2010/03/12 00:00 [revised]
PHST- 2010/03/16 00:00 [accepted]
PHST- 2010/03/27 06:00 [entrez]
PHST- 2010/03/27 06:00 [pubmed]
PHST- 2010/09/14 06:00 [medline]
AID - S0141-8130(10)00089-9 [pii]
AID - 10.1016/j.ijbiomac.2010.03.008 [doi]
PST - ppublish
SO  - Int J Biol Macromol. 2010 Jun;46(5):487-92. doi: 10.1016/j.ijbiomac.2010.03.008. 
      Epub 2010 Mar 23.