PMID- 20338890
OWN - NLM
STAT- MEDLINE
DCOM- 20110311
LR  - 20221207
IS  - 1462-0332 (Electronic)
IS  - 1462-0324 (Linking)
VI  - 49
IP  - 7
DP  - 2010 Jul
TI  - A single centre retrospective analysis of AECG classification criteria for 
      primary Sjogren's syndrome based on 112 minor salivary gland biopsies in a 
      Japanese population.
PG  - 1290-3
LID - 10.1093/rheumatology/keq075 [doi]
AB  - OBJECTIVE: To assess the usefulness and performance of the American European 
      Consensus Group (AECG) criteria based on minor salivary gland biopsy (MSGB) in 
      Japanese patients with primary SS. METHODS: Among 208 MSGB cases, we 
      retrospectively selected 112 subjects who satisfied the complete set of AECG 
      classification criteria. Of the 112 subjects studied, 63 primary SS patients and 
      49 non-SS group subjects were classified according to the AECG criteria. The 
      contribution of subjective and objective components was statistically analysed. 
      RESULTS: Sex, dry eye, Saxon test, Schirmer's test, anti-SSA/Ro antibody, MSGB 
      grading and sialography statistically contributed to the diagnosis. Multiple 
      logistic regression analysis showed that positive MSGB [odds ratio (OR) 105; 95% 
      CI 13, 849), positive anti-SSA/Ro antibody (OR 96; 95% CI 10, 923), a positive 
      Saxon test (OR 46; 95% CI, 6, 340) and the existence of dry eye (OR 8, 95% CI 2, 
      43) were associated with the diagnosis of primary SS. Among the components of the 
      AECG criteria, MSGB and anti-SSA/Ro antibody were very strong contributors. 
      Furthermore, the abnormal-finding positive rate in sialography significantly 
      correlated with MSGB grading (P-value for trend = 0.0006), although other 
      subjective and objective components were not associated with MSGB grading. 
      CONCLUSION: The usefulness of the AECG criteria for Japanese primary SS patients 
      was confirmed.
FAU - Nakamura, Hideki
AU  - Nakamura H
AD  - Department of Immunology and Rheumatology, Unit of Translational Medicine, 
      Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, 
      Nagasaki City, Nagasaki 852-8501, Japan. nhideki@nagasaki-u.ac.jp
FAU - Kawakami, Atsushi
AU  - Kawakami A
FAU - Iwamoto, Naoki
AU  - Iwamoto N
FAU - Okada, Akitomo
AU  - Okada A
FAU - Yamasaki, Satoshi
AU  - Yamasaki S
FAU - Tamai, Mami
AU  - Tamai M
FAU - Ida, Hiroaki
AU  - Ida H
FAU - Takagi, Yukinori
AU  - Takagi Y
FAU - Hayashi, Tomayoshi
AU  - Hayashi T
FAU - Aoyagi, Kiyoshi
AU  - Aoyagi K
FAU - Nakamura, Takashi
AU  - Nakamura T
FAU - Eguchi, Katsumi
AU  - Eguchi K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100324
PL  - England
TA  - Rheumatology (Oxford)
JT  - Rheumatology (Oxford, England)
JID - 100883501
SB  - IM
MH  - Aged
MH  - Asian People
MH  - Biopsy
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Predictive Value of Tests
MH  - Retrospective Studies
MH  - Salivary Gland Diseases/*classification/pathology/physiopathology
MH  - Salivary Glands, Minor/*metabolism
MH  - Severity of Illness Index
MH  - Sjogren's Syndrome/*classification/pathology/physiopathology
MH  - Statistics as Topic
EDAT- 2010/03/27 06:00
MHDA- 2011/03/12 06:00
CRDT- 2010/03/27 06:00
PHST- 2010/03/27 06:00 [entrez]
PHST- 2010/03/27 06:00 [pubmed]
PHST- 2011/03/12 06:00 [medline]
AID - keq075 [pii]
AID - 10.1093/rheumatology/keq075 [doi]
PST - ppublish
SO  - Rheumatology (Oxford). 2010 Jul;49(7):1290-3. doi: 10.1093/rheumatology/keq075. 
      Epub 2010 Mar 24.