PMID- 20345253
OWN - NLM
STAT- MEDLINE
DCOM- 20110411
LR  - 20211020
IS  - 1557-8534 (Electronic)
IS  - 1547-3287 (Print)
IS  - 1547-3287 (Linking)
VI  - 19
IP  - 11
DP  - 2010 Nov
TI  - Signaling from fibroblast growth factor receptor 2 in immature hematopoietic 
      cells facilitates donor hematopoiesis after intra-bone marrow-bone marrow 
      transplantation.
PG  - 1679-86
LID - 10.1089/scd.2009.0370 [doi]
AB  - Fibroblast growth factor (FGF) and FGF receptor (FGFR) are expressed in various 
      cells including endothelial progenitor cells and hematopoietic cells. The 
      interaction between FGF and FGFR is associated with the proliferation, migration, 
      and survival of these cells. In this report, we examined the effects of FGFR2 
      signaling on hematopoiesis in immature hematopoietic cells, using mutant mice in 
      which a constitutively active form of FGFR2 mutant was caused to be overexpressed 
      by the Tie2 promoter (FGFR2 Tg mice). Under normal conditions, hematopoiesis of 
      FGFR2 Tg mice and wild type (Wt) mice do not differ significantly, except for the 
      weight and cell numbers of the thymus. However, the c-kit(+)Sca-1(+)lineage(-) bone 
      marrow cells (BMCs) of FGFR2 Tg mice facilitate the formation of colony-forming 
      units of culture. When these BMCs were transplanted into the recipient bone 
      marrow (intra-bone marrow-bone marrow transplantation), there was better 
      reconstitution of donor hematopoietic cells. In the in vitro experiment, the 
      c-kit(+)Sca-1(+)lineage(-) BMCs from FGFR2 Tg mice showed fewer apoptotic cells 
      than those from Wt mice. These results suggest that the antiapoptotic effect of 
      FGFR2 signaling facilitates the hematopoiesis of FGFR2 Tg mice.
FAU - Shigematsu, Akio
AU  - Shigematsu A
AD  - First Department of Pathology, Kansai Medical University, Moriguchi City, Osaka, 
      Japan.
FAU - Shi, Ming
AU  - Shi M
FAU - Okigaki, Mitsuhiko
AU  - Okigaki M
FAU - Adachi, Yasushi
AU  - Adachi Y
FAU - Koike, Naoko
AU  - Koike N
FAU - Che, Jishan
AU  - Che J
FAU - Iwasaki, Masayoshi
AU  - Iwasaki M
FAU - Matsubara, Hiroaki
AU  - Matsubara H
FAU - Imamura, Masahiro
AU  - Imamura M
FAU - Ikehara, Susumu
AU  - Ikehara S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100910
PL  - United States
TA  - Stem Cells Dev
JT  - Stem cells and development
JID - 101197107
RN  - 0 (Antigens, Ly)
RN  - 0 (Ly6a protein, mouse)
RN  - 0 (Membrane Proteins)
RN  - 0 (RNA, Messenger)
RN  - EC 2.7.10.1 (Proto-Oncogene Proteins c-kit)
RN  - EC 2.7.10.1 (Receptor, Fibroblast Growth Factor, Type 2)
SB  - IM
MH  - Animals
MH  - Antigens, Ly/genetics/metabolism
MH  - Bone Marrow Transplantation/*methods
MH  - Cell Lineage
MH  - Hematopoiesis
MH  - Hematopoietic Stem Cell Transplantation/*methods
MH  - Hematopoietic Stem Cells/cytology/*physiology
MH  - Humans
MH  - Membrane Proteins/genetics/metabolism
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Transgenic
MH  - Proto-Oncogene Proteins c-kit/genetics/metabolism
MH  - RNA, Messenger/metabolism
MH  - Receptor, Fibroblast Growth Factor, Type 2/genetics/*metabolism
MH  - Signal Transduction/*physiology
PMC - PMC3128310
EDAT- 2010/03/30 06:00
MHDA- 2011/04/13 06:00
PMCR- 2010/03/26
CRDT- 2010/03/30 06:00
PHST- 2010/03/30 06:00 [entrez]
PHST- 2010/03/30 06:00 [pubmed]
PHST- 2011/04/13 06:00 [medline]
PHST- 2010/03/26 00:00 [pmc-release]
AID - 10.1089/scd.2009.0370 [pii]
AID - 10.1089/scd.2009.0370 [doi]
PST - ppublish
SO  - Stem Cells Dev. 2010 Nov;19(11):1679-86. doi: 10.1089/scd.2009.0370. Epub 2010 
      Sep 10.