PMID- 20345476
OWN - NLM
STAT- MEDLINE
DCOM- 20100701
LR  - 20220330
IS  - 1349-7006 (Electronic)
IS  - 1347-9032 (Linking)
VI  - 101
IP  - 5
DP  - 2010 May
TI  - DJ-1: a novel independent prognostic marker for survival in glottic squamous cell 
      carcinoma.
PG  - 1320-5
LID - 10.1111/j.1349-7006.2010.01531.x [doi]
AB  - DJ-1 is frequently overexpressed in a large variety of solid tumors, but the DJ-1 
      expression in laryngeal squamous cell cancer and its clinical/prognostic 
      significance is unclear. We aimed to evaluate DJ-1 protein expression in glottic 
      squamous cell carcinoma (GSCC) and to correlate this with clinicopathological 
      data including patient survival. The expression of DJ-1 in GSCCs (60) and 
      adjacent normal tissue (44) was assessed by immunohistochemistry and western blot 
      analysis. In addition, the role of DJ-1 was investigated in tumorigenesis by 
      transfecting DJ1-specific siRNA into laryngeal squamous cell carcinoma (LSCC) 
      Hep-2 cells. Our data showed that positive expression of DJ-1 was found in 85% of 
      GSCCs. In univariate survival analysis of the GSCC cohorts, a highly significant 
      association between DJ-1 expression with shortened patient overall survival 
      (5-year survival rate 92.9%vs 66.6%; P = 0.001; log rank test) was demonstrated. 
      In multivariate analyses, DJ-1, tumor grading, and pT status were significant 
      prognostic parameters for shortened patient overall survival. Furthermore, siRNA 
      targeting DJ-1 can effectively inhibit DJ-1 expression, resulting in enhanced 
      apoptosis and less proliferation of Hep-2 cells. We concluded that DJ-1 
      overexpression might be a novel independent molecular marker for poor prognosis 
      (shortened overall survival) of patients with GSCC.
FAU - Zhu, Xiao-Lin
AU  - Zhu XL
AD  - Department of Otorhinolaryngology Head and Neck Surgery, The First Affiliated 
      Hospital, Guangzhou, China.
FAU - Wang, Zhang-Feng
AU  - Wang ZF
FAU - Lei, Wen-Bin
AU  - Lei WB
FAU - Zhuang, Hui-Wen
AU  - Zhuang HW
FAU - Jiang, Hong-Yan
AU  - Jiang HY
FAU - Wen, Wei-Ping
AU  - Wen WP
LA  - eng
PT  - Journal Article
DEP - 20100211
PL  - England
TA  - Cancer Sci
JT  - Cancer science
JID - 101168776
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (Intracellular Signaling Peptides and Proteins)
RN  - 0 (Oncogene Proteins)
RN  - EC 3.1.2.- (PARK7 protein, human)
RN  - EC 3.1.2.- (Protein Deglycase DJ-1)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Apoptosis
MH  - Biomarkers, Tumor/*analysis
MH  - Carcinoma, Squamous Cell/*mortality/pathology
MH  - Female
MH  - *Glottis
MH  - Humans
MH  - Intracellular Signaling Peptides and Proteins/*analysis/physiology
MH  - Laryngeal Neoplasms/*mortality/pathology
MH  - Male
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Oncogene Proteins/*analysis/physiology
MH  - Prognosis
MH  - Protein Deglycase DJ-1
EDAT- 2010/03/30 06:00
MHDA- 2010/07/02 06:00
CRDT- 2010/03/30 06:00
PHST- 2010/03/30 06:00 [entrez]
PHST- 2010/03/30 06:00 [pubmed]
PHST- 2010/07/02 06:00 [medline]
AID - CAS1531 [pii]
AID - 10.1111/j.1349-7006.2010.01531.x [doi]
PST - ppublish
SO  - Cancer Sci. 2010 May;101(5):1320-5. doi: 10.1111/j.1349-7006.2010.01531.x. Epub 
      2010 Feb 11.