PMID- 20347860
OWN - NLM
STAT- MEDLINE
DCOM- 20101105
LR  - 20131121
IS  - 1095-6808 (Electronic)
IS  - 0091-3022 (Linking)
VI  - 31
IP  - 3
DP  - 2010 Jul
TI  - Glutamatergic synaptic transmission in neuroendocrine cells: Basic principles and 
      mechanisms of plasticity.
PG  - 296-306
LID - 10.1016/j.yfrne.2010.03.002 [doi]
AB  - Glutamate synapses drive the output of neuroendocrine cells in the hypothalamus, 
      but until recently, relatively little was known about the fundamental properties 
      of transmission at these synapses. Here we review recent advances in the 
      understanding of glutamate signals in magnocellular neurosecretory cells (MNCs) 
      in the paraventricular (PVN) and supraoptic nuclei (SON) of the hypothalamus that 
      serve as the last step in synaptic integration before neurohormone release. While 
      these synapses exhibit many similarities with other glutamate synapses described 
      throughout the brain, they also exhibit a number of unique properties that are 
      particularly well suited to the physiology of this system and will be discussed 
      here. In addition, a number of recent studies begin to provide insights into new 
      forms of synaptic plasticity that may be common in other brain regions, but in 
      these cells, may serve important adaptive roles.
CI  - Copyright 2010 Elsevier Inc. All rights reserved.
FAU - Iremonger, Karl J
AU  - Iremonger KJ
AD  - Hotchkiss Brain Institute and Department of Physiology and Pharmacology, 
      University of Calgary, Calgary, AB, Canada T2N 4N1.
FAU - Benediktsson, Adrienne M
AU  - Benediktsson AM
FAU - Bains, Jaideep S
AU  - Bains JS
LA  - eng
GR  - Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20100327
PL  - United States
TA  - Front Neuroendocrinol
JT  - Frontiers in neuroendocrinology
JID - 7513292
RN  - 3KX376GY7L (Glutamic Acid)
SB  - IM
MH  - Action Potentials/physiology
MH  - Animals
MH  - Glutamic Acid/*metabolism
MH  - Humans
MH  - Models, Biological
MH  - Neuroendocrine Cells/*metabolism/*physiology
MH  - Neuronal Plasticity/*physiology
MH  - Paraventricular Hypothalamic Nucleus/metabolism/physiology
MH  - Synaptic Transmission/*physiology
EDAT- 2010/03/30 06:00
MHDA- 2010/11/06 06:00
CRDT- 2010/03/30 06:00
PHST- 2009/12/14 00:00 [received]
PHST- 2010/03/21 00:00 [revised]
PHST- 2010/03/23 00:00 [accepted]
PHST- 2010/03/30 06:00 [entrez]
PHST- 2010/03/30 06:00 [pubmed]
PHST- 2010/11/06 06:00 [medline]
AID - S0091-3022(10)00024-5 [pii]
AID - 10.1016/j.yfrne.2010.03.002 [doi]
PST - ppublish
SO  - Front Neuroendocrinol. 2010 Jul;31(3):296-306. doi: 10.1016/j.yfrne.2010.03.002. 
      Epub 2010 Mar 27.