PMID- 20349238
OWN - NLM
STAT- MEDLINE
DCOM- 20120109
LR  - 20221207
IS  - 1437-160X (Electronic)
IS  - 0172-8172 (Linking)
VI  - 31
IP  - 9
DP  - 2011 Sep
TI  - Polymorphisms of tumor necrosis factor-alpha promoter region for susceptibility to 
      HLA-B27-positive ankylosing spondylitis in Korean population.
PG  - 1167-75
LID - 10.1007/s00296-010-1434-1 [doi]
AB  - This study designed to assess the relationship between tumor necrosis factor 
      (TNF)-alpha promoter polymorphisms and disease susceptibility to human leukocyte 
      antigen (HLA)-B27-positive ankylosing spondylitis (AS). One hundred and nineteen 
      HLA-B27(+) AS patients, 95 HLA-B27(+) healthy controls, and 135 random healthy 
      controls were enrolled in this study. Six single nucleotide polymorphisms (SNPs) 
      of the TNF-alpha promoter at positions -1031T/C, -863C/A, -857C/T, -646G/A, -308G/A, 
      and -238G/A were analyzed. Differences between groups were evaluated using the 
      chi-square test or Fisher's exact test. Haplotypes from each SNP were 
      constructed, and differences in haplotypic frequencies between groups were 
      evaluated. There were significant differences in the allelic and genotypic 
      frequencies of 1031T/C, -863C/A, and -857C/T TNF-alpha promoters polymorphisms 
      between HLA-B27(+) AS patients and random controls, but not between patients with 
      AS and HLA-B27(+) healthy individuals. TNF-alpha polymorphisms did not influence the 
      extra-spinal clinical features in patients with AS. The haplotypic sequence 
      -1031T/-863C/-857C/-308G increased the risk of susceptibility to AS compared to 
      random controls (P (corr) < 0.001, OR = 2.756, 95% CI = 1.894-4.010), whereas the 
      sequence -1031C/-863A/-857C/-308G appeared to be associated with decreased 
      susceptibility to AS compared to random controls (P (corr) = 0.006, OR = 0.396, 
      95% CI = 0.231-0.679). This study indicates that TNF-alpha promoter polymorphism 
      between controls and AS patients with HLA-B27(+) genetic background is not 
      associated with susceptibility to AS. However, TNF-alpha polymorphism, irrespective 
      of HLA-B27, increases risk of susceptibility to AS in general population.
FAU - Chung, Won-Tae
AU  - Chung WT
AD  - Department of Internal Medicine, Dong-A University College of Medicine, Busan, 
      South Korea.
FAU - Choe, Jung-Yoon
AU  - Choe JY
FAU - Jang, Won Cheoul
AU  - Jang WC
FAU - Park, Su Min
AU  - Park SM
FAU - Ahn, Young Chang
AU  - Ahn YC
FAU - Yoon, Il Kyu
AU  - Yoon IK
FAU - Kim, Tae-Hwan
AU  - Kim TH
FAU - Nam, Youn-Hyoung
AU  - Nam YH
FAU - Park, Sung-Hoon
AU  - Park SH
FAU - Lee, Sung-Won
AU  - Lee SW
FAU - Kim, Seong-Kyu
AU  - Kim SK
LA  - eng
PT  - Journal Article
DEP - 20100328
PL  - Germany
TA  - Rheumatol Int
JT  - Rheumatology international
JID - 8206885
RN  - 0 (HLA-B27 Antigen)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Asian People/genetics/statistics & numerical data
MH  - Female
MH  - Gene Frequency
MH  - Genetic Predisposition to Disease/*genetics
MH  - HLA-B27 Antigen/*genetics
MH  - Haplotypes/genetics
MH  - Humans
MH  - Male
MH  - *Polymorphism, Genetic
MH  - Polymorphism, Single Nucleotide
MH  - Promoter Regions, Genetic/*genetics
MH  - Spondylitis, Ankylosing/*genetics
MH  - Tumor Necrosis Factor-alpha/*genetics
EDAT- 2010/03/30 06:00
MHDA- 2012/01/10 06:00
CRDT- 2010/03/30 06:00
PHST- 2009/11/25 00:00 [received]
PHST- 2010/03/12 00:00 [accepted]
PHST- 2010/03/30 06:00 [entrez]
PHST- 2010/03/30 06:00 [pubmed]
PHST- 2012/01/10 06:00 [medline]
AID - 10.1007/s00296-010-1434-1 [doi]
PST - ppublish
SO  - Rheumatol Int. 2011 Sep;31(9):1167-75. doi: 10.1007/s00296-010-1434-1. Epub 2010 
      Mar 28.