PMID- 20349525
OWN - NLM
STAT- MEDLINE
DCOM- 20100714
LR  - 20211020
IS  - 1862-1783 (Electronic)
IS  - 1673-1581 (Print)
IS  - 1673-1581 (Linking)
VI  - 11
IP  - 4
DP  - 2010 Apr
TI  - Accumulation of 1-deoxynojirimycin in silkworm, Bombyx mori L.
PG  - 286-91
LID - 10.1631/jzus.B0900344 [doi]
AB  - 1-deoxynojirimycin (1-DNJ) contents in the silkworm, Bombyx mori, at different 
      developmental stages and tissues were investigated by using reverse-phase 
      high-performance liquid chromatography. The 1-DNJ contents of silkworm larvae 
      change significantly with their developmental stages. The male larvae showed 
      higher accumulation efficiency of 1-DNJ than the females and also a significant 
      variation was observed among the silkworm strains. The present results show that 
      tissue distribution of 1-DNJ was significantly higher in blood, digestive juice, 
      and alimentary canal, but no 1-DNJ was observed in the silkgland. Moreover, 1-DNJ 
      was not found in silkworms fed with artificial diet that does not contain 
      mulberry leaf powder. This proves that silkworms obtain 1-DNJ from mulberry 
      leaves; they could not synthesize 1-DNJ by themselves. The accumulation and 
      excretion of 1-DNJ change periodically during the larval stage. There was no 
      1-DNJ in the newly-hatched larvae and 1-DNJ was mainly accumulated during the 
      early and middle stages of every instar, while excreted at later stages of larval 
      development. Further, it is possible to extract 1-DNJ from the larval feces and 
      it is optimal to develop the 1-DNJ related products for diabetic auxiliary 
      therapy.
FAU - Yin, Hao
AU  - Yin H
AD  - Key Laboratory of Agricultural Ecology and Environment, College of Forestry, 
      Shandong Agricultural University, Taian 271018, China.
FAU - Shi, Xin-qin
AU  - Shi XQ
FAU - Sun, Bo
AU  - Sun B
FAU - Ye, Jing-jing
AU  - Ye JJ
FAU - Duan, Zu-an
AU  - Duan ZA
FAU - Zhou, Xiao-ling
AU  - Zhou XL
FAU - Cui, Wei-zheng
AU  - Cui WZ
FAU - Wu, Xiao-feng
AU  - Wu XF
LA  - eng
PT  - Journal Article
PL  - China
TA  - J Zhejiang Univ Sci B
JT  - Journal of Zhejiang University. Science. B
JID - 101236535
RN  - 19130-96-2 (1-Deoxynojirimycin)
SB  - IM
MH  - 1-Deoxynojirimycin/chemistry/*pharmacokinetics
MH  - Animal Feed
MH  - Animals
MH  - Bombyx/embryology/*metabolism
MH  - Chromatography, High Pressure Liquid/methods
MH  - Female
MH  - Larva/metabolism
MH  - Male
MH  - Morus
MH  - Plant Leaves/metabolism
MH  - Time Factors
MH  - Tissue Distribution
PMC - PMC2852545
EDAT- 2010/03/30 06:00
MHDA- 2010/07/16 06:00
PMCR- 2010/04/01
CRDT- 2010/03/30 06:00
PHST- 2010/03/30 06:00 [entrez]
PHST- 2010/03/30 06:00 [pubmed]
PHST- 2010/07/16 06:00 [medline]
PHST- 2010/04/01 00:00 [pmc-release]
AID - 10.1631/jzus.B0900344 [doi]
PST - ppublish
SO  - J Zhejiang Univ Sci B. 2010 Apr;11(4):286-91. doi: 10.1631/jzus.B0900344.