PMID- 20349685
OWN - NLM
STAT- MEDLINE
DCOM- 20100420
LR  - 20130912
IS  - 0011-4162 (Print)
IS  - 0011-4162 (Linking)
VI  - 85
IP  - 2
DP  - 2010 Feb
TI  - Safety and efficacy of sertaconazole nitrate cream 2% in the treatment of tinea 
      pedis interdigitalis: a subgroup analysis.
PG  - 107-11
AB  - Sertaconazole nitrate is a broad-spectrum antifungal agent indicated in the 
      United States for the treatment of tinea pedis interdigitalis. The objective of 
      this subgroup analysis was to evaluate the safety and efficacy of sertaconazole 
      nitrate cream 2%, specifically in participants with tinea pedis interdigitalis 
      (ie, fungal skin disease of the toe web) of dermatophyte origin. A total of 92 
      participants were included in this analysis. The primary end points were 
      eradication of the pathogen (confirmed by fungal culture results) and reduction 
      in total clinical score (TCS) of at least 2 points. Secondary end points included 
      reducing signs and symptoms and reporting adverse events (AEs). After 4 weeks of 
      treatment, 88.8% (79/89) of evaluable participants achieved success on the 
      primary end points. Most participants also demonstrated substantial improvement 
      in signs and symptoms after 4 weeks of treatment: 63.7% (58/91) were free of 
      erythema, 33.0% (30/91) were free of desquamation, and 91.2% (83/91) were free of 
      itch. The rate of reported AEs was low (8.7% [8/92]), and none were considered 
      serious. These findings indicate that sertaconazole nitrate cream 2% is highly 
      safe and effective in the treatment of tinea pedis interdigitalis.
FAU - Borelli, Claudia
AU  - Borelli C
AD  - Department of Dermatology and Allergology, Ludwig-Maximilians-Universitat 
      Munchen, Munich. Germany. claudia.borelli@med.uni-muenchen.de
FAU - Korting, Hans Christian
AU  - Korting HC
FAU - Bodeker, Rolf-Hasso
AU  - Bodeker RH
FAU - Neumeister, Claudia
AU  - Neumeister C
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Cutis
JT  - Cutis
JID - 0006440
RN  - 0 (Antifungal Agents)
RN  - 0 (Imidazoles)
RN  - 0 (Ointments)
RN  - 0 (Thiophenes)
RN  - 72W71I16EG (sertaconazole)
SB  - IM
MH  - Administration, Topical
MH  - Antifungal Agents/*administration & dosage/adverse effects
MH  - Female
MH  - Humans
MH  - Imidazoles/*administration & dosage/adverse effects
MH  - Male
MH  - Ointments
MH  - Thiophenes/*administration & dosage/adverse effects
MH  - Tinea Pedis/*drug therapy
EDAT- 2010/03/31 06:00
MHDA- 2010/04/21 06:00
CRDT- 2010/03/31 06:00
PHST- 2010/03/31 06:00 [entrez]
PHST- 2010/03/31 06:00 [pubmed]
PHST- 2010/04/21 06:00 [medline]
PST - ppublish
SO  - Cutis. 2010 Feb;85(2):107-11.