PMID- 20350254
OWN - NLM
STAT- MEDLINE
DCOM- 20100618
LR  - 20100413
IS  - 1365-2060 (Electronic)
IS  - 0785-3890 (Linking)
VI  - 42
IP  - 3
DP  - 2010 Apr
TI  - Interleukin-18 gene polymorphism and markers of subclinical atherosclerosis. The 
      Cardiovascular Risk in Young Finns Study.
PG  - 223-30
LID - 10.3109/07853891003769940 [doi]
AB  - BACKGROUND AND AIM: Interleukin-18 (IL-18) is a pro-atherosclerotic cytokine. We 
      wanted to evaluate whether IL-18 gene polymorphism associates independently of 
      risk factors, with early subclinical markers of atherosclerosis (intima-media 
      thickness (IMT), coronary artery compliance (CAC), and flow-mediated dilatation 
      (FMD)) in a population of young healthy Caucasian adults. METHODS: This study was 
      based on the on-going Cardiovascular Risk in Young Finns Study consisting of 2260 
      young adults, mean age being 31.7 (range 24-39 years) (1247 women and 1013 men). 
      RESULTS: Five studied tagSNPs formed six major haplotypes, which accounted for 
      99.9% of all variation of the IL-18 gene. According to adjusted analysis of 
      variance, the IL-18 gene polymorphism did not associate with subclinical 
      atherosclerosis in the whole study population. However, one major haplotype 
      associated differently among men and women with IMT (P = 0.011). Male carriers of 
      a major CCTgT haplotype (n = 441) seemed to have a lower IMT when compared to the 
      non-carriers (-0.016 mm, 95% confidence interval (CI) -0.028 to -0.004, P = 
      0.014). Among women no significant associations were observed. CONCLUSIONS: Among 
      all study subjects, the polymorphism of the IL-18 gene is not associated with 
      subclinical markers of atherosclerosis. However, among men one major IL-18 
      haplotype seemed to associate with substantially lower IMT values.
FAU - Hernesniemi, Jussi A
AU  - Hernesniemi JA
AD  - Department of Clinical Chemistry, University of Tampere and Tampere University 
      Hospital, Finland. jussi.hernesniemi@uta.fi
FAU - Heikkila, Arto
AU  - Heikkila A
FAU - Raitakari, Olli T
AU  - Raitakari OT
FAU - Kahonen, Mika
AU  - Kahonen M
FAU - Juonala, Markus
AU  - Juonala M
FAU - Hutri-Kahonen, Nina
AU  - Hutri-Kahonen N
FAU - Marniemi, Jukka
AU  - Marniemi J
FAU - Viikari, Jorma
AU  - Viikari J
FAU - Lehtimaki, Terho
AU  - Lehtimaki T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Ann Med
JT  - Annals of medicine
JID - 8906388
RN  - 0 (Interleukin-18)
SB  - IM
MH  - Adult
MH  - Atherosclerosis/epidemiology/*genetics/physiopathology
MH  - Cardiovascular Diseases/epidemiology/genetics/physiopathology
MH  - Female
MH  - Finland/epidemiology
MH  - Gene Frequency
MH  - Haplotypes
MH  - Humans
MH  - Interleukin-18/*genetics
MH  - Male
MH  - *Polymorphism, Genetic
MH  - Risk Factors
MH  - Young Adult
EDAT- 2010/03/31 06:00
MHDA- 2010/06/19 06:00
CRDT- 2010/03/31 06:00
PHST- 2010/03/31 06:00 [entrez]
PHST- 2010/03/31 06:00 [pubmed]
PHST- 2010/06/19 06:00 [medline]
AID - 10.3109/07853891003769940 [doi]
PST - ppublish
SO  - Ann Med. 2010 Apr;42(3):223-30. doi: 10.3109/07853891003769940.