PMID- 20350431
OWN - NLM
STAT- MEDLINE
DCOM- 20100629
LR  - 20131121
IS  - 1008-8830 (Print)
IS  - 1008-8830 (Linking)
VI  - 12
IP  - 3
DP  - 2010 Mar
TI  - [NMDAR expression in the cochlear nucleus and hearing damage in neonatal rats 
      with hyperbilirubinemia].
PG  - 201-4
AB  - OBJECTIVE: To study the role of N-methyl-D-aspartate-receptor (NMDAR) expression 
      in the development of hearing damage in neonatal rats with hyperbilirubinemia. 
      METHODS: Sixty seven-day-old Sprague-Dawley rats were randomly injected with 
      bilirubin of 100 microg/g (low-dose treatment group) or 200 microg/g (high-dose 
      treatment group) or normal saline (control group). Auditory brainstem response 
      (ABR) was examined. The concentrations of bilirubin in blood and brain were 
      measured. NMDAR expression in the cochlear nucleus slices was examined by 
      immunohistochemistry assay. RESULTS: ABR reflecting threshold obviously 
      increased, and I, II and III wave latency as well as I-II, II-III and I-III 
      interval were more prolonged in the two bilirubin treatment groups when compared 
      with the control group. The NMDAR expression in the cochlear nucleuse in the two 
      bilirubin treatment groups was obviously lower than that in the control group. 
      The NMDAR expression in the cochlear nucleuse was negatively correlated with the 
      brain bilirubin content and the ABR reflecting threshold in the two bilirubin 
      treatment groups. CONCLUSIONS: An increased NMDAR activity may play an important 
      role in hearing damage following hyperbilirubinemia.
FAU - Li, Ke-Fang
AU  - Li KF
AD  - Department of Otolaryngology, Third Affiliated Hospital, Zhengzhou University, 
      Zhengzhou 450052, China.
FAU - Du, Kai-Xian
AU  - Du KX
FAU - Jiang, Yue-Xing
AU  - Jiang YX
FAU - Dong, Xue-Lei
AU  - Dong XL
FAU - Zhang, Yan
AU  - Zhang Y
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Zhongguo Dang Dai Er Ke Za Zhi
JT  - Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics
JID - 100909956
RN  - 0 (Receptors, N-Methyl-D-Aspartate)
RN  - RFM9X3LJ49 (Bilirubin)
SB  - IM
MH  - Animals
MH  - Animals, Newborn
MH  - Bilirubin/analysis
MH  - Cochlear Nucleus/*chemistry
MH  - Evoked Potentials, Auditory, Brain Stem
MH  - Female
MH  - Hearing Disorders/*etiology
MH  - Hyperbilirubinemia/complications/*metabolism
MH  - Immunohistochemistry
MH  - Male
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Receptors, N-Methyl-D-Aspartate/*analysis
EDAT- 2010/03/31 06:00
MHDA- 2010/06/30 06:00
CRDT- 2010/03/31 06:00
PHST- 2010/03/31 06:00 [entrez]
PHST- 2010/03/31 06:00 [pubmed]
PHST- 2010/06/30 06:00 [medline]
AID - 1008-8830(2010)03-0201-04 [pii]
PST - ppublish
SO  - Zhongguo Dang Dai Er Ke Za Zhi. 2010 Mar;12(3):201-4.