PMID- 20350583
OWN - NLM
STAT- MEDLINE
DCOM- 20100630
LR  - 20100426
IS  - 1872-7972 (Electronic)
IS  - 0304-3940 (Linking)
VI  - 475
IP  - 2
DP  - 2010 May 14
TI  - Increased plasma levels of brain-derived neurotrophic factor in patients with 
      long-term bipolar disorder.
PG  - 95-8
LID - 10.1016/j.neulet.2010.03.055 [doi]
AB  - Recent data indicate that neurotrophins may play a role in the physiopathology of 
      bipolar disorder (BD) and may be useful as biomarkers of the disease. The aim of 
      this study was to evaluate the plasma concentrations of brain-derived 
      neurotrophic factor (BDNF) in BD patients, and to correlate their levels with 
      clinical parameters. BDNF was measured in plasma from 53 BD type I subjects (34 
      during mania and 19 during euthymia) and 38 healthy controls by enzyme-linked 
      immuno-sorbent assay (ELISA). Patients were assessed by a structured clinical 
      interview (Mini-plus), Young mania and Hamilton depression rating scales. Plasma 
      BDNF levels were significantly increased in patients with mania (P</=0.001) and 
      euthymia (P</=0.001) when compared with controls, but did not correlate with any 
      clinical parameters. BDNF concentration was higher in BD patients with 10 or more 
      years of disease. BDNF plasma levels were increased in BD patients, mainly in 
      those with a longer course of disease. In line with previous studies, it is 
      conceivable that BDNF may play a role in the pathophysiology of BD.
CI  - Copyright 2010 Elsevier Ireland Ltd. All rights reserved.
FAU - Barbosa, Izabela Guimaraes
AU  - Barbosa IG
AD  - Programa de Neurociencias, Universidade Federal de Minas Gerais (UFMG), Avenida 
      Antonio Carlos 6627, 31270-901 Campus Pampulha, Belo Horizonte, Minas Gerais, 
      Brazil.
FAU - Huguet, Rodrigo Barreto
AU  - Huguet RB
FAU - Mendonca, Vanessa Amaral
AU  - Mendonca VA
FAU - Neves, Fernando Silva
AU  - Neves FS
FAU - Reis, Helton Jose
AU  - Reis HJ
FAU - Bauer, Moises Evandro
AU  - Bauer ME
FAU - Janka, Zoltan
AU  - Janka Z
FAU - Palotas, Andras
AU  - Palotas A
FAU - Teixeira, Antonio Lucio
AU  - Teixeira AL
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100327
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Adult
MH  - Bipolar Disorder/*blood/physiopathology
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Time Factors
EDAT- 2010/03/31 06:00
MHDA- 2010/07/01 06:00
CRDT- 2010/03/31 06:00
PHST- 2010/02/06 00:00 [received]
PHST- 2010/03/19 00:00 [revised]
PHST- 2010/03/22 00:00 [accepted]
PHST- 2010/03/31 06:00 [entrez]
PHST- 2010/03/31 06:00 [pubmed]
PHST- 2010/07/01 06:00 [medline]
AID - S0304-3940(10)00364-2 [pii]
AID - 10.1016/j.neulet.2010.03.055 [doi]
PST - ppublish
SO  - Neurosci Lett. 2010 May 14;475(2):95-8. doi: 10.1016/j.neulet.2010.03.055. Epub 
      2010 Mar 27.