PMID- 20350923
OWN - NLM
STAT- MEDLINE
DCOM- 20101207
LR  - 20221207
IS  - 1934-2403 (Electronic)
IS  - 1530-891X (Linking)
VI  - 16
IP  - 4
DP  - 2010 Jul-Aug
TI  - Pilot study to evaluate the effect of short-term improvement in vitamin D status 
      on glucose tolerance in patients with type 2 diabetes mellitus.
PG  - 600-8
LID - 10.4158/EP09300.OR [doi]
AB  - OBJECTIVE: To study the effect of improvement in vitamin D status on glucose 
      tolerance in Asian Indian patients with moderately controlled type 2 diabetes 
      mellitus (T2DM). METHODS: This randomized, double-blind, placebo-controlled pilot 
      study was conducted in 28 Asian Indian patients with T2DM. Study participants 
      were randomly assigned to a vitamin D-treated group (group D) or a placebo group 
      (group P). Serum 25-hydroxyvitamin D, hemoglobin A1c, and serum fructosamine 
      levels were measured, and an oral glucose tolerance test (OGTT) was performed in 
      all patients at baseline and 4 weeks after intervention. During the OGTT, plasma 
      glucose and serum insulin levels were measured at 0, 30, 60, 90, and 120 minutes. 
      The unpaired t test was used to compare the groups at baseline and to compare the 
      differences in changes from baseline to 4 weeks between the 2 study groups. 
      RESULTS: Group D and group P were similar with respect to their fasting plasma 
      glucose and serum insulin concentrations, post-OGTT plasma glucose and serum 
      insulin levels, and hemoglobin A1c and fructosamine values at baseline. Serum 
      25-hydroxyvitamin D levels increased significantly in group D at 4 weeks. No 
      significant differences were found between the groups at baseline and 4 weeks 
      with respect to serum fructosamine, fasting plasma glucose and serum insulin, 
      post-OGTT plasma glucose and serum insulin levels, and homeostasis model 
      assessment of insulin resistance. CONCLUSION: In this study, short-term 
      improvement in vitamin D status was not associated with improvement in glucose 
      tolerance, insulin secretion, or insulin sensitivity in Asian Indian patients 
      with moderately controlled T2DM.
FAU - Parekh, Deepal
AU  - Parekh D
AD  - Department of Endocrinology, Seth Gordhandas Sunderdas Medical College and King 
      Edward Memorial Hospital, Parel, Mumbai, Maharashtra, India.
FAU - Sarathi, Vijaya
AU  - Sarathi V
FAU - Shivane, Vyankatesh K
AU  - Shivane VK
FAU - Bandgar, Tushar R
AU  - Bandgar TR
FAU - Menon, Padma S
AU  - Menon PS
FAU - Shah, Nalini S
AU  - Shah NS
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - United States
TA  - Endocr Pract
JT  - Endocrine practice : official journal of the American College of Endocrinology 
      and the American Association of Clinical Endocrinologists
JID - 9607439
RN  - 0 (Blood Glucose)
RN  - 0 (Glycated Hemoglobin A)
RN  - 0 (Insulin)
RN  - 0 (hemoglobin A1c protein, human)
RN  - 1C6V77QF41 (Cholecalciferol)
RN  - 21343-40-8 (25-Hydroxyvitamin D 2)
RN  - 4429-04-3 (Fructosamine)
RN  - P6YZ13C99Q (Calcifediol)
SB  - IM
MH  - 25-Hydroxyvitamin D 2/blood
MH  - Adult
MH  - Asian People
MH  - Blood Glucose/analysis
MH  - Body Mass Index
MH  - Calcifediol/blood
MH  - Cholecalciferol/*therapeutic use
MH  - Diabetes Mellitus, Type 2/*blood/complications/*physiopathology
MH  - Dietary Supplements
MH  - Double-Blind Method
MH  - Female
MH  - Fructosamine/blood
MH  - Glucose Intolerance/*physiopathology
MH  - Glycated Hemoglobin/analysis
MH  - Homeostasis
MH  - Humans
MH  - India
MH  - Insulin/blood
MH  - Insulin Resistance
MH  - Male
MH  - Middle Aged
MH  - Pilot Projects
MH  - Vitamin D Deficiency/blood/complications/*drug therapy
EDAT- 2010/03/31 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/03/31 06:00
PHST- 2010/03/31 06:00 [entrez]
PHST- 2010/03/31 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - S1530-891X(20)40805-5 [pii]
AID - 10.4158/EP09300.OR [doi]
PST - ppublish
SO  - Endocr Pract. 2010 Jul-Aug;16(4):600-8. doi: 10.4158/EP09300.OR.