PMID- 20350991
OWN - NLM
STAT- MEDLINE
DCOM- 20100603
LR  - 20201216
IS  - 1468-201X (Electronic)
IS  - 1355-6037 (Linking)
VI  - 96
IP  - 7
DP  - 2010 Apr
TI  - Gender differences in clinical presentation and surgical outcome of aortic 
      stenosis.
PG  - 539-45
LID - 10.1136/hrt.2009.186650 [doi]
AB  - BACKGROUND: Little is known about the gender differences of patients undergoing 
      aortic valve replacement (AVR) for isolated severe aortic stenosis. METHODS AND 
      RESULTS: 408 consecutive patients (215 women and 193 men; p=0.9) were analysed. 
      At presentation, women were older (73.7+/-9.3 years vs men 66.5+/-11.5 years; 
      p<0.001), more symptomatic (New York Heart Association (NYHA) class: women 
      2.3+/-0.7 vs men 2.0+/-0.65; p<0.001), and presented with smaller valve areas 
      (women 0.6+/-0.2 cm(2) vs men 0.7+/-0.2 cm(2); p<0.001) and higher mean pressure 
      gradients (women 67.3+/-19.2 mm Hg vs men 62.2+/-20.0 mm Hg, p=0.001). Despite 
      older age and more advanced disease in women, operative mortality did not differ. 
      Survival after AVR by Kaplan-Meier analysis tended to be even better in women 
      (92.8%, 89.8%, 81.4% vs men 89.1%, 86.6%, 76.3% at 1, 2 and 5 years, p=0.31). 
      After division into age quintiles, the outcome of women was significantly better 
      in patients older than 79 years (p=0.005). After adjustment for clinical 
      characteristics, gender did not predict operative mortality and late outcome. 
      Despite physical improvement in both groups after surgery, women remained more 
      symptomatic (NYHA class: women 1.6+/-0.7 vs men 1.3+/-0.4; p=0.001). CONCLUSION: 
      Although women referred to AVR are older and more symptomatic, operative and 
      long-term mortality are not increased. In the oldest age group of 79 years and 
      older, women even have a better outcome, presumably due to a longer mean life 
      expectancy.
FAU - Fuchs, Christina
AU  - Fuchs C
AD  - Department of Cardiology, Medical University of Vienna, University Hospital, 
      Waehringer Guertel 18-20, A-1090 Vienna, Austria. 
      julia.mascherbauer@meduniwien.ac.at
FAU - Mascherbauer, Julia
AU  - Mascherbauer J
FAU - Rosenhek, Raphael
AU  - Rosenhek R
FAU - Pernicka, Elisabeth
AU  - Pernicka E
FAU - Klaar, Ursula
AU  - Klaar U
FAU - Scholten, Christine
AU  - Scholten C
FAU - Heger, Maria
AU  - Heger M
FAU - Wollenek, Gregor
AU  - Wollenek G
FAU - Czerny, Martin
AU  - Czerny M
FAU - Maurer, Gerald
AU  - Maurer G
FAU - Baumgartner, Helmut
AU  - Baumgartner H
LA  - eng
PT  - Journal Article
PL  - England
TA  - Heart
JT  - Heart (British Cardiac Society)
JID - 9602087
SB  - IM
CIN - Heart. 2011 Jan;97(2):165; author reply 165-6. PMID: 21163896
MH  - Aged
MH  - Aortic Valve/pathology/*surgery
MH  - Aortic Valve Stenosis/mortality/pathology/*surgery
MH  - Coronary Angiography
MH  - Echocardiography
MH  - Female
MH  - Follow-Up Studies
MH  - *Heart Valve Prosthesis
MH  - *Heart Valve Prosthesis Implantation
MH  - Humans
MH  - Kaplan-Meier Estimate
MH  - Male
MH  - Preoperative Care
MH  - Sex Factors
MH  - Treatment Outcome
EDAT- 2010/03/31 06:00
MHDA- 2010/06/04 06:00
CRDT- 2010/03/31 06:00
PHST- 2010/03/31 06:00 [entrez]
PHST- 2010/03/31 06:00 [pubmed]
PHST- 2010/06/04 06:00 [medline]
AID - 96/7/539 [pii]
AID - 10.1136/hrt.2009.186650 [doi]
PST - ppublish
SO  - Heart. 2010 Apr;96(7):539-45. doi: 10.1136/hrt.2009.186650.