PMID- 20351057
OWN - NLM
STAT- MEDLINE
DCOM- 20100622
LR  - 20211020
IS  - 1549-5485 (Electronic)
IS  - 1072-0502 (Print)
IS  - 1072-0502 (Linking)
VI  - 17
IP  - 4
DP  - 2010 Apr
TI  - Synaptic plasticity and NO-cGMP-PKG signaling coordinately regulate ERK-driven 
      gene expression in the lateral amygdala and in the auditory thalamus following 
      Pavlovian fear conditioning.
PG  - 221-35
LID - 10.1101/lm.1592510 [doi]
AB  - We have recently hypothesized that NO-cGMP-PKG signaling in the lateral nucleus 
      of the amygdala (LA) during auditory fear conditioning coordinately regulates 
      ERK-driven transcriptional changes in both auditory thalamic (MGm/PIN) and LA 
      neurons that serve to promote pre- and postsynaptic alterations at thalamo-LA 
      synapses, respectively. In the present series of experiments, we show that 
      N-methyl-D-aspartate receptor (NMDAR)-driven synaptic plasticity and NO-cGMP-PKG 
      signaling in the LA regulate the training-induced expression of ERK and the 
      ERK-driven immediate early genes (IEGs) Arc/Arg3.1, c-Fos, and EGR-1 in the LA 
      and the MGm/PIN. Rats receiving intra-LA infusion of the NR2B selective 
      antagonist Ifenprodil, the NOS inhibitor 7-Ni, or the PKG inhibitor 
      Rp-8-Br-PET-cGMPS exhibited significant decreases in ERK activation and in the 
      training-induced expression of all three IEGs in the LA and MGm/PIN while 
      intra-LA infusion of the PKG activator 8-Br-cGMP had the opposite effect. 
      Remarkably, those rats given intra-LA infusion of the membrane impermeable NO 
      scavenger c-PTIO exhibited significant decreases in ERK activation and ERK-driven 
      IEG expression in the MGm/PIN, but not in the LA. Together with our previous 
      experiments, these results suggest that synaptic plasticity and the NO-cGMP-PKG 
      signaling pathway promote fear memory consolidation, in part, by regulating 
      ERK-driven transcription in both the LA and the MGm/PIN. They further suggest 
      that synaptic plasticity in the LA during fear conditioning promotes ERK-driven 
      transcription in MGm/PIN neurons via NO-driven "retrograde signaling."
FAU - Ota, Kristie T
AU  - Ota KT
AD  - Department of Psychology, Yale University, New Haven, Connecticut 06520, USA.
FAU - Monsey, Melissa S
AU  - Monsey MS
FAU - Wu, Melissa S
AU  - Wu MS
FAU - Young, Grace J
AU  - Young GJ
FAU - Schafe, Glenn E
AU  - Schafe GE
LA  - eng
GR  - R01 MH073949/MH/NIMH NIH HHS/United States
GR  - R25 NS080686/NS/NINDS NIH HHS/United States
GR  - MH 073949/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20100329
PL  - United States
TA  - Learn Mem
JT  - Learning & memory (Cold Spring Harbor, N.Y.)
JID - 9435678
RN  - 0 (Enzyme Inhibitors)
RN  - 0 (Excitatory Amino Acid Antagonists)
RN  - EC 2.7.11.12 (Cyclic GMP-Dependent Protein Kinases)
RN  - EC 2.7.11.24 (Extracellular Signal-Regulated MAP Kinases)
RN  - H2D2X058MU (Cyclic GMP)
SB  - IM
MH  - Acoustic Stimulation/adverse effects
MH  - Amygdala/drug effects/*physiology
MH  - Animals
MH  - Behavior, Animal
MH  - Conditioning, Classical/drug effects/*physiology
MH  - Cyclic GMP/metabolism
MH  - Cyclic GMP-Dependent Protein Kinases/metabolism
MH  - Enzyme Inhibitors/pharmacology
MH  - Excitatory Amino Acid Antagonists/pharmacology
MH  - Extracellular Signal-Regulated MAP Kinases/*metabolism
MH  - *Fear/drug effects
MH  - Gene Expression Regulation/drug effects/*physiology
MH  - Male
MH  - Models, Biological
MH  - Neuronal Plasticity/drug effects/genetics/*physiology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Signal Transduction/drug effects/*physiology
MH  - Thalamus/drug effects/*physiology
MH  - Time Factors
PMC - PMC2852617
EDAT- 2010/03/31 06:00
MHDA- 2010/06/23 06:00
PMCR- 2011/04/01
CRDT- 2010/03/31 06:00
PHST- 2010/03/31 06:00 [entrez]
PHST- 2010/03/31 06:00 [pubmed]
PHST- 2010/06/23 06:00 [medline]
PHST- 2011/04/01 00:00 [pmc-release]
AID - 17/4/221 [pii]
AID - OtaLM15925 [pii]
AID - 10.1101/lm.1592510 [doi]
PST - epublish
SO  - Learn Mem. 2010 Mar 29;17(4):221-35. doi: 10.1101/lm.1592510. Print 2010 Apr.