PMID- 20352006
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20211020
IS  - 1998-3662 (Electronic)
IS  - 0971-4065 (Print)
IS  - 0971-4065 (Linking)
VI  - 19
IP  - 1
DP  - 2009 Jan
TI  - Is carbon dioxide a safe and good alternative for diatrizoate meglumine as a 
      contrast in digital subtraction angiography?
PG  - 15-9
LID - 10.4103/0971-4065.50675 [doi]
AB  - Contrast-induced nephropathy is well-known sequelae of iodinated contrast 
      (diatrizoate meglumine). Carbon dioxide (CO(2)) can be used as an alternative 
      contrast agent. The aim of this study was to compare the renal injury and the 
      quality of images of aortogram using iodinated contrast versus CO(2) using 
      digital subtraction angiography (DSA). This prospective randomized study was done 
      in 29 healthy dogs using DSA aortogram. Dogs were randomly assigned to receive 
      iodinated contrast or CO(2). 6-F pigtail catheter was introduced via femoral 
      artery approach to perform aortogram under general anesthesia. Serum creatinine 
      (S.Cr.) and urinary enzymes, namely: N-acetyl D-glucosaminidase (NAG), alanine 
      aminopeptidase (AAP), and gamma glutamyl transferase (GGT), were measured before 
      and 48 hours after aortogram. There was no change in S.Cr. in both the groups. 
      Significantly more enzymuria was seen following iodinated contrast than CO(2). 
      Enzymuria pre and postaortogram following the iodinated contrast was GGT: 14.9 
      +/- 5.92 vs. 26.2 +/- 15.1 (P = 0.001), NAG: 1.63 +/- 0.90 vs. 3.6 +/- 2.14 (P = 
      0.0001), and AAP: 1.51 +/- 0.75 vs. 3.38 2.41 (P = 0.001), and in the CO(2) group 
      was GGT: 15.5 +/- 4.9 vs. 21.1 +/- 9.04 (P = 0.02), NAG: 2.12 +/- 1.06 vs. 3.82 
      3.27 (P = 0.08), and AAP: 1.28 +/- 0.76 vs. 2.51 +/- 1.72 (P = 0.03). More than 
      50% increase over the preprocedural value was significantly less following CO(2). 
      Images obtained with iodinated contrast were superior to those with CO(2,) 
      however, the quality of image with CO(2) was adequate for delineation of the 
      renal artery and major branches. Both iodinated contrast and CO(2) cause 
      significant enzymuria. More severe enzymuria (>50% increase) was seen 
      significantly less with the use of CO(2). Quality of images is better with 
      iodinated contrast.
FAU - Hegde, U N
AU  - Hegde UN
AD  - Department of Nephrology, Muljibhai Patel Urological Hospital, Nadiad, India.
FAU - Khanapet, M S
AU  - Khanapet MS
FAU - Rajapurkar, M M
AU  - Rajapurkar MM
FAU - Gang, S D
AU  - Gang SD
FAU - Gohel, K D
AU  - Gohel KD
FAU - Rane, G
AU  - Rane G
FAU - Parikh, P
AU  - Parikh P
FAU - Patil, D
AU  - Patil D
FAU - Desai, T
AU  - Desai T
FAU - Patil, P
AU  - Patil P
FAU - Kelawala, N
AU  - Kelawala N
LA  - eng
PT  - Journal Article
PL  - India
TA  - Indian J Nephrol
JT  - Indian journal of nephrology
JID - 8914356
PMC - PMC2845188
OTO - NOTNLM
OT  - CO2 angiogram
OT  - contrast nephropathy
OT  - dog aortogram
OT  - enzymuria
COIS- Conflict of Interest: None declared.
EDAT- 2009/01/01 00:00
MHDA- 2009/01/01 00:01
PMCR- 2009/01/01
CRDT- 2010/03/31 06:00
PHST- 2010/03/31 06:00 [entrez]
PHST- 2009/01/01 00:00 [pubmed]
PHST- 2009/01/01 00:01 [medline]
PHST- 2009/01/01 00:00 [pmc-release]
AID - IJN-19-15 [pii]
AID - 10.4103/0971-4065.50675 [doi]
PST - ppublish
SO  - Indian J Nephrol. 2009 Jan;19(1):15-9. doi: 10.4103/0971-4065.50675.