PMID- 20354783
OWN - NLM
STAT- MEDLINE
DCOM- 20100820
LR  - 20211020
IS  - 1573-6903 (Electronic)
IS  - 0364-3190 (Linking)
VI  - 35
IP  - 7
DP  - 2010 Jul
TI  - Hydrogen-rich saline protects against spinal cord injury in rats.
PG  - 1111-8
LID - 10.1007/s11064-010-0162-y [doi]
AB  - In the present study, we examined the mechanisms of hydrogen-rich saline, a 
      reported therapeutic antioxidant, in the treatment of acute spinal cord contusion 
      injury. Male Sprague-Dawley rats were used to produce a standardized model of 
      contuses spinal cord injury (125 kdyn force). Hydrogen-rich saline was injected 
      intraperitoneally (5 ml/kg) immediately, and at 24 and 48 h after injury. All 
      rats were sacrificed at 72 h after spinal cord injury (SCI). Apoptotic cell 
      death, oxidative stress, inflammation, level of Brain derived neurotrophic factor 
      (BDNF) were evaluated. In addition, locomotor behavior was assessed using the 
      Basso, Beattice and Bresnahan (BBB) scale. We observed that administration of 
      hydrogen-rich saline decreased the number of apoptotic cells, suppressed 
      oxidative stress, and improved locomotor functions. Hydrogen-rich saline 
      increased the release of BDNF. In conclusion, hydrogen-rich saline reduced acute 
      spinal cord contusion injury, possibly by reduction of oxidative stress and 
      elevation of BDNF.
FAU - Chen, Chengwen
AU  - Chen C
AD  - Department of Anesthesiology, Changzheng Hospital, Second Military Medical 
      University, 200003, Shanghai, People's Republic of China.
FAU - Chen, Qianbo
AU  - Chen Q
FAU - Mao, Yanfei
AU  - Mao Y
FAU - Xu, Shengming
AU  - Xu S
FAU - Xia, Chunyan
AU  - Xia C
FAU - Shi, Xueyin
AU  - Shi X
FAU - Zhang, John H
AU  - Zhang JH
FAU - Yuan, Hongbin
AU  - Yuan H
FAU - Sun, Xuejun
AU  - Sun X
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100331
PL  - United States
TA  - Neurochem Res
JT  - Neurochemical research
JID - 7613461
RN  - 0 (Antioxidants)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 451W47IQ8X (Sodium Chloride)
RN  - 4Y8F71G49Q (Malondialdehyde)
RN  - 7YNJ3PO35Z (Hydrogen)
RN  - EC 1.11.1.7 (Peroxidase)
RN  - EC 3.4.22.- (Caspases)
SB  - IM
MH  - Animals
MH  - Antioxidants/*therapeutic use
MH  - Apoptosis
MH  - Brain-Derived Neurotrophic Factor/metabolism
MH  - Caspases/metabolism
MH  - Cell Death
MH  - Hindlimb/physiopathology
MH  - Hydrogen/*therapeutic use
MH  - Male
MH  - Malondialdehyde/metabolism
MH  - Oxidative Stress
MH  - Peroxidase/metabolism
MH  - Protein Carbonylation
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Sodium Chloride/*therapeutic use
MH  - Spinal Cord/metabolism/pathology/physiopathology
MH  - Spinal Cord Injuries/metabolism/pathology/physiopathology/*prevention & control
EDAT- 2010/04/01 06:00
MHDA- 2010/08/21 06:00
CRDT- 2010/04/01 06:00
PHST- 2010/03/22 00:00 [accepted]
PHST- 2010/04/01 06:00 [entrez]
PHST- 2010/04/01 06:00 [pubmed]
PHST- 2010/08/21 06:00 [medline]
AID - 10.1007/s11064-010-0162-y [doi]
PST - ppublish
SO  - Neurochem Res. 2010 Jul;35(7):1111-8. doi: 10.1007/s11064-010-0162-y. Epub 2010 
      Mar 31.