PMID- 20356127
OWN - NLM
STAT- MEDLINE
DCOM- 20100421
LR  - 20181201
IS  - 1944-8244 (Print)
IS  - 1944-8244 (Linking)
VI  - 1
IP  - 11
DP  - 2009 Nov
TI  - Antimicrobial activities and cellular responses to natural silicate clays and 
      derivatives modified by cationic alkylamine salts.
PG  - 2556-64
LID - 10.1021/am900479q [doi]
AB  - Nanometer-scale silicate platelet (NSP) materials were previously developed by 
      increasing the interlayer space and exfoliation of layered silicate clays such as 
      montmorillonite and synthetic fluorinated mica by the process of polyamine 
      exfoliation. In this study, the antibacterial activity and cytotoxicity of these 
      nanometer-scale silicate clays were evaluated. The derivatives of NSP (NSP-S) 
      which were modified by C18-fatty amine salts via ionic exchange association 
      exhibited the highest antibacterial activity in the aqueous state among all 
      clays. The high antibacterial activity, however, was accompanied by elevated 
      cytotoxicity. The variations of cell surface markers (CD29 and CD44) and type I 
      collagen expression of fibroblasts treated with the clays were measured to 
      clarify the mechanism of the silicate-induced cytotoxicity. The signal 
      transduction pathway involved the downregulation of 
      extracellular-signal-regulated kinase (ERK), which appeared to participate in 
      silicate-induced cytotoxicity. This study helped to understand the antibacterial 
      potential of NSP and the interaction of natural and modified clays with cellular 
      activities.
FAU - Hsu, Shan-Hui
AU  - Hsu SH
AD  - Institute of Polymer Science and Engineering, National Taiwan University, Taipei 
      10617 Taiwan, Republic of China. shhsu@ntu.edu.tw
FAU - Tseng, Hsiang-Jung
AU  - Tseng HJ
FAU - Hung, Huey-Shan
AU  - Hung HS
FAU - Wang, Ming-Chien
AU  - Wang MC
FAU - Hung, Chiung-Hui
AU  - Hung CH
FAU - Li, Pei-Ru
AU  - Li PR
FAU - Lin, Jiang-Jen
AU  - Lin JJ
LA  - eng
PT  - Journal Article
PL  - United States
TA  - ACS Appl Mater Interfaces
JT  - ACS applied materials & interfaces
JID - 101504991
RN  - 0 (Aluminum Silicates)
RN  - 0 (Amines)
RN  - 0 (Anti-Infective Agents)
RN  - 0 (Cations)
RN  - 0 (Collagen Type I)
RN  - 0 (Hyaluronan Receptors)
RN  - 0 (Integrin beta1)
RN  - 0 (Salts)
RN  - 0 (Silicates)
RN  - 1302-78-9 (Bentonite)
RN  - EC 2.7.11.24 (Extracellular Signal-Regulated MAP Kinases)
RN  - T1FAD4SS2M (Clay)
SB  - IM
MH  - Aluminum Silicates/*pharmacology
MH  - Amines/*chemistry
MH  - Animals
MH  - Anti-Infective Agents/*pharmacology
MH  - Bentonite/pharmacology
MH  - Cations
MH  - Cattle
MH  - Cell Death/drug effects
MH  - Clay
MH  - Collagen Type I/genetics/metabolism
MH  - Colony Count, Microbial
MH  - Endothelial Cells/*cytology/drug effects/enzymology
MH  - Escherichia coli/drug effects/growth & development/ultrastructure
MH  - Extracellular Signal-Regulated MAP Kinases/metabolism
MH  - Fibroblasts/*cytology/drug effects/enzymology
MH  - Gene Expression Regulation/drug effects
MH  - Humans
MH  - Hyaluronan Receptors/metabolism
MH  - Integrin beta1/metabolism
MH  - Microbial Sensitivity Tests
MH  - Phosphorylation/drug effects
MH  - Salts/*chemistry
MH  - Silicates/*pharmacology
MH  - Staphylococcus aureus/drug effects/growth & development/ultrastructure
EDAT- 2010/04/02 06:00
MHDA- 2010/04/22 06:00
CRDT- 2010/04/02 06:00
PHST- 2010/04/02 06:00 [entrez]
PHST- 2010/04/02 06:00 [pubmed]
PHST- 2010/04/22 06:00 [medline]
AID - 10.1021/am900479q [doi]
PST - ppublish
SO  - ACS Appl Mater Interfaces. 2009 Nov;1(11):2556-64. doi: 10.1021/am900479q.