PMID- 20356506
OWN - NLM
STAT- MEDLINE
DCOM- 20160423
LR  - 20181201
IS  - 0578-1426 (Print)
IS  - 0578-1426 (Linking)
VI  - 49
IP  - 2
DP  - 2010 Feb
TI  - [The efficacy of donepezil for post-stroke aphasia: a pilot case control study.].
PG  - 115-8
AB  - OBJECTIVE: To evaluate the efficacy of donepezil for post-stroke aphasia. 
      METHODS: Sixty patients with acute post-stroke aphasia were divided into 
      treatment group and a control group. All patients had been treated for secondary 
      prevention according to the guideline. The treatment group received donepezil 
      hydrochloride (5 mg/d) for 12 weeks. The efficacy of treatment was measured by 
      comparing the changes of scores of Western Aphasia Battery (WAB) between baseline 
      and 12 weeks later. RESULTS: Compared with the baseline, the changes of scores of 
      all items of WAB and Aphasia Quotient (AQ) in both group after 12 weeks follow-up 
      were great, however, the change of AQ was significantly greater in donepezil 
      group (34.14 +/- 17.70)than that in control group (20.69 +/- 17.26)(P = 0.004). 
      The patients in donepezil group also showed significant recovery in spontaneous 
      speech, comprehension, repetition, and naming than those in control group (P < 
      0.05). The rate of significant improving in donepezil group was 60.0% which was 
      significantly greater than that in control group (26.7%) (P = 0.009). CONCLUSION: 
      There are spontaneous recovery of post-stroke aphasia within 3 months. Donepezil 
      may facilitate the recovery in spontaneous speech, comprehension, repetition, and 
      naming functions.
FAU - Chen, Ying
AU  - Chen Y
AD  - Department of Neurology, Renji Hospital Affiliated to Shanghai Jiaotong 
      University School of Medicine, Shanghai 200127, China.
FAU - Li, Yan-Sheng
AU  - Li YS
FAU - Wang, Zhi-Ying
AU  - Wang ZY
FAU - Xu, Qun
AU  - Xu Q
FAU - Shi, Guo-Wen
AU  - Shi GW
FAU - Lin, Yan
AU  - Lin Y
LA  - chi
PT  - Journal Article
PL  - China
TA  - Zhonghua Nei Ke Za Zhi
JT  - Zhonghua nei ke za zhi
JID - 16210490R
SB  - IM
MH  - *Aphasia
MH  - Case-Control Studies
MH  - Humans
MH  - *Stroke
EDAT- 2010/04/02 06:00
MHDA- 2016/04/24 06:00
CRDT- 2010/04/02 06:00
PHST- 2010/04/02 06:00 [entrez]
PHST- 2010/04/02 06:00 [pubmed]
PHST- 2016/04/24 06:00 [medline]
PST - ppublish
SO  - Zhonghua Nei Ke Za Zhi. 2010 Feb;49(2):115-8.