PMID- 20356631
OWN - NLM
STAT- MEDLINE
DCOM- 20100721
LR  - 20111117
IS  - 1872-7603 (Electronic)
IS  - 0165-0378 (Linking)
VI  - 85
IP  - 1
DP  - 2010 May
TI  - Interaction between HLA-G and monocyte/macrophages in human pregnancy.
PG  - 40-6
LID - 10.1016/j.jri.2010.02.004 [doi]
AB  - Several lines of evidence suggest that the human leukocyte antigen (HLA)-G play a 
      key role in the regulation of human pregnancy. A sub-population of cells highly 
      represented at the decidua belong to the myeloid-derived monocyte/macrophage 
      lineage, which potentially interact with HLA-G expressing cells. It is proposed 
      that HLA-G protects decidual trophoblasts from lysis by blocking the effector 
      function of decidual monocyte/macrophages. The interaction between HLA-G and 
      monocyte/macrophages may therefore contribute to a successful pregnancy. Here we 
      examine existing knowledge on the convergent role of HLA-G and 
      monocyte/macrophages in pregnancy and define the synergy that exists between 
      these two elements in the decidua. Key features of the HLA-G gene product are 
      discussed followed by the main characteristics of decidual monocyte/macrophages. 
      A hypothetical model for the interaction between HLA-G and monocyte/macrophage 
      cells at the fetal-maternal interface is proposed.
CI  - Copyright (c) 2010 Elsevier Ireland Ltd. All rights reserved.
FAU - Shakhawat, Ayesha
AU  - Shakhawat A
AD  - Department of Biological Sciences, University of Essex, Wivenhoe Park, 
      Colchester, Essex CO4 3SQ, United Kingdom.
FAU - Shaikly, Valerie
AU  - Shaikly V
FAU - Elzatma, Essam
AU  - Elzatma E
FAU - Mavrakos, Emmanouil
AU  - Mavrakos E
FAU - Jabeen, Asma
AU  - Jabeen A
FAU - Fernandez, Nelson
AU  - Fernandez N
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20100330
PL  - Ireland
TA  - J Reprod Immunol
JT  - Journal of reproductive immunology
JID - 8001906
RN  - 0 (HLA Antigens)
RN  - 0 (HLA-G Antigens)
RN  - 0 (Histocompatibility Antigens Class I)
SB  - IM
MH  - Female
MH  - HLA Antigens/*immunology
MH  - HLA-G Antigens
MH  - Histocompatibility Antigens Class I/*immunology
MH  - Humans
MH  - Macrophages/*immunology
MH  - Monocytes/*immunology
MH  - Placental Circulation/immunology
MH  - Pregnancy/*immunology
MH  - Pregnancy Complications/immunology
RF  - 71
EDAT- 2010/04/02 06:00
MHDA- 2010/07/22 06:00
CRDT- 2010/04/02 06:00
PHST- 2009/09/10 00:00 [received]
PHST- 2010/02/10 00:00 [revised]
PHST- 2010/02/17 00:00 [accepted]
PHST- 2010/04/02 06:00 [entrez]
PHST- 2010/04/02 06:00 [pubmed]
PHST- 2010/07/22 06:00 [medline]
AID - S0165-0378(10)00046-X [pii]
AID - 10.1016/j.jri.2010.02.004 [doi]
PST - ppublish
SO  - J Reprod Immunol. 2010 May;85(1):40-6. doi: 10.1016/j.jri.2010.02.004. Epub 2010 
      Mar 30.