PMID- 20356852
OWN - NLM
STAT- MEDLINE
DCOM- 20100914
LR  - 20220310
IS  - 1464-3685 (Electronic)
IS  - 0300-5771 (Linking)
VI  - 39
IP  - 3
DP  - 2010 Jun
TI  - Prenatal paracetamol exposure and asthma: further evidence against confounding.
PG  - 790-4
LID - 10.1093/ije/dyq049 [doi]
AB  - BACKGROUND: Observational studies have reported an association between maternal 
      use of paracetamol in pregnancy and childhood asthma, which was not explained by 
      measured confounding factors. However, it is possible that this relation might be 
      confounded by unmeasured behavioural factors linked to paracetamol usage; if that 
      were the case, effects of similar magnitude of partner's paracetamol use and/or 
      postnatal maternal use would be expected. METHODS: In the Avon Longitudinal Study 
      of Parents and Children (ALSPAC), a population-based birth cohort, we compared 
      the univariate effects of maternal use of paracetamol in pregnancy on risk of 
      doctor-diagnosed asthma, wheeze and elevated immunoglobulin E (IgE) in the 
      offspring at 7 years of age, with the univariate effects of partner's use and 
      postnatal maternal use on these phenotypes. RESULTS: Maternal use of paracetamol 
      in pregnancy was strongly associated with all outcomes. Partner's use was very 
      weakly associated with asthma but not associated with wheezing or IgE. Postnatal 
      maternal use was associated with asthma and wheezing, though less strongly than 
      was prenatal use, and was not associated with IgE. On mutual adjustment, the 
      effects of maternal use in pregnancy on all outcomes were not substantially 
      attenuated, whereas the effects of partner's use on asthma, and of postnatal 
      maternal use on asthma and wheezing, were reduced. CONCLUSIONS: These findings 
      suggest that the relation between maternal use of paracetamol in pregnancy and 
      childhood asthma is unlikely to be confounded by unmeasured behavioural factors 
      linked to paracetamol use.
FAU - Shaheen, Seif O
AU  - Shaheen SO
AD  - Respiratory Epidemiology and Public Health Group, National Heart and Lung 
      Institute, Imperial College London, London, UK. s.shaheen@imperial.ac.uk
FAU - Newson, Roger B
AU  - Newson RB
FAU - Smith, George Davey
AU  - Smith GD
FAU - Henderson, A John
AU  - Henderson AJ
LA  - eng
GR  - G9815508/MRC_/Medical Research Council/United Kingdom
GR  - WT_/Wellcome Trust/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100330
PL  - England
TA  - Int J Epidemiol
JT  - International journal of epidemiology
JID - 7802871
RN  - 0 (Analgesics, Non-Narcotic)
RN  - 362O9ITL9D (Acetaminophen)
SB  - IM
MH  - Acetaminophen/*adverse effects
MH  - Analgesics, Non-Narcotic/*adverse effects
MH  - Asthma/*epidemiology
MH  - Child
MH  - Confounding Factors, Epidemiologic
MH  - Female
MH  - Humans
MH  - Maternal Behavior
MH  - Pregnancy
MH  - Prenatal Exposure Delayed Effects/*epidemiology
MH  - United Kingdom/epidemiology
EDAT- 2010/04/02 06:00
MHDA- 2010/09/15 06:00
CRDT- 2010/04/02 06:00
PHST- 2010/04/02 06:00 [entrez]
PHST- 2010/04/02 06:00 [pubmed]
PHST- 2010/09/15 06:00 [medline]
AID - dyq049 [pii]
AID - 10.1093/ije/dyq049 [doi]
PST - ppublish
SO  - Int J Epidemiol. 2010 Jun;39(3):790-4. doi: 10.1093/ije/dyq049. Epub 2010 Mar 30.