PMID- 20358027
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20240419
IS  - 2092-7363 (Electronic)
IS  - 2092-7355 (Print)
IS  - 2092-7355 (Linking)
VI  - 2
IP  - 2
DP  - 2010 Apr
TI  - Association Between Serum IgE Levels and the CTLA4 +49A/G and FCER1B -654C/T 
      Polymorphisms in Korean Children With Asthma.
PG  - 127-33
LID - 10.4168/aair.2010.2.2.127 [doi]
AB  - PURPOSE: T cells play a central role in cell-mediated immunity, atopic disease, 
      and asthma. The balance of CD28/cytotoxic T-lymphocyte antigen 4 (CTLA4)-derived 
      signal transduction plays an important role in the activation of T cells and an 
      increased immunoglobulin E (IgE) response. The aim of the current study was to 
      investigate the association between polymorphisms in the genes encoding both 
      CTLA4 and the high-affinity IgE receptor 1B (FCER1B) and serum IgE levels in 
      Korean children with asthma. METHODS: We enrolled 238 controls and 742 children 
      with asthma. The CTLA4 +49A/G and FCER1B -654C/T polymorphisms were genotyped by 
      PCR-restriction fragment length polymorphism analysis. RESULTS: We observed no 
      difference in the distribution of CTLA4 +49A/G among controls, children with 
      asthma, and those with atopic asthma. In contrast, the GA genotype of CTLA4 
      +49A/G in children with atopic asthma was significantly higher compared to that 
      in those with non-atopic asthma. Moreover, significantly higher log 
      Dp/Df-specific IgE levels were found in children with asthma and those with 
      atopic asthma carrying one or two copies of the CTLA4 +49A versus those 
      homozygous for +49G. Gene-gene interactions between CTLA4 and FCER1B with the 
      heterozygote and homozygote of variant genotypes were associated with the log 
      Dp/Df-specific IgE levels, but not asthma development. In addition, children with 
      Dp/Df (+) asthma carried an elevated combined genotype of risk allele compared to 
      those with Dp/Df (-) asthma. CONCLUSIONS: The CTLA4 +49A/G polymorphism may 
      contribute to the production of IgE in Korean children with asthma, especially in 
      Dp/Df-specific IgE levels, but not in the direct development of asthma. In 
      addition, Dp/Df-specific IgE levels with a FCER1B -654C/T polymorphism may 
      involve additive effects.
FAU - Oh, Kyu-Young
AU  - Oh KY
AD  - Korean Minjok Leadership Academy, Korea.
FAU - Kang, Mi-Jin
AU  - Kang MJ
FAU - Choi, Won-Ah
AU  - Choi WA
FAU - Kwon, Ji-Won
AU  - Kwon JW
FAU - Kim, Byoung-Ju
AU  - Kim BJ
FAU - Yu, Jinho
AU  - Yu J
FAU - Hong, Soo-Jong
AU  - Hong SJ
LA  - eng
PT  - Journal Article
DEP - 20100324
PL  - Korea (South)
TA  - Allergy Asthma Immunol Res
JT  - Allergy, asthma & immunology research
JID - 101518382
PMC - PMC2846736
OTO - NOTNLM
OT  - Asthma
OT  - CTLA4
OT  - Dermatophagoides farinae
OT  - Dermatophagoides pteronyssinus
OT  - FCER1B
OT  - immunoglobulin E
OT  - polymorphism
COIS- There are no financial or other issues that might lead to conflict of interest.
EDAT- 2010/04/02 06:00
MHDA- 2010/04/02 06:01
PMCR- 2010/04/01
CRDT- 2010/04/02 06:00
PHST- 2009/11/27 00:00 [received]
PHST- 2010/02/09 00:00 [accepted]
PHST- 2010/04/02 06:00 [entrez]
PHST- 2010/04/02 06:00 [pubmed]
PHST- 2010/04/02 06:01 [medline]
PHST- 2010/04/01 00:00 [pmc-release]
AID - 10.4168/aair.2010.2.2.127 [doi]
PST - ppublish
SO  - Allergy Asthma Immunol Res. 2010 Apr;2(2):127-33. doi: 10.4168/aair.2010.2.2.127. 
      Epub 2010 Mar 24.