PMID- 20359090
OWN - NLM
STAT- MEDLINE
DCOM- 20110627
LR  - 20100402
IS  - 2096-7993 (Print)
IS  - 2096-7993 (Linking)
VI  - 23
IP  - 24
DP  - 2009 Dec
TI  - [Expression and pathobiological significance of Col I, Col IV and Fn in laryngeal 
      squamous cell carcinomas].
PG  - 1130-3
AB  - OBJECTIVE: To investigate the expression of collagen type I (Col I), collagen 
      type IV (Col IV) and fibronectin (Fn) in laryngeal squamous cell carcinomas 
      (LSCC) and their pathobiological relationship with invasion and metastasis of 
      tumor. METHOD: The expression of Col I, Col IV and Fn was detected by 
      immunohistochemistry method in normal tissue of latero-carcinoma and tissue of 
      carcinoma in 60 specimens of LSCC. Integral optical density (iOD) was detected by 
      image analysis of computer and was analyzed by SPSS13.0. RESULT: The expression 
      of Col I was obvious and integrity. The expression of Col IV and Fn of basal 
      membrane was like intact line-shape appearance and Fn of interstitial substance 
      appeared like a complete network in the normal tissue of latero-carcinoma. Their 
      expression decreased gradually and their integrity was broken and disappeared 
      gradually from well to poorly differentiated LSCC. Their expressions also fell 
      off with the tumor size, clinical stage and cervical lymphatic metastasis 
      gradually and consistently in LSCC. Their variances were statistical significance 
      separately (P<0.05 or P<0.01). CONCLUSION: The expression of Col I, Col IV and Fn 
      was closely related to tumor invasion, the regional lymph node metastasis and 
      other some pathobiological features in LSCC. A detection of Col I, Col IV and Fn 
      was of definite significance on a better comprehension of the possibility of 
      metastasis, choice of surgery and prognosis.
FAU - Zhang, Haiqin
AU  - Zhang H
AD  - Department of Otorhinolaryngology Head and Neck Surgery, Affiliated Hospital of 
      Medical College, Qingdao University, Qingdao, 266003, China.
FAU - Li, Wei
AU  - Li W
FAU - Shang, Wei
AU  - Shang W
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
JT  - Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical 
      otorhinolaryngology, head, and neck surgery
JID - 101303164
RN  - 0 (Collagen Type I)
RN  - 0 (Collagen Type IV)
RN  - 0 (Fibronectins)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Carcinoma, Squamous Cell/*metabolism/pathology
MH  - Collagen Type I/*metabolism
MH  - Collagen Type IV/*metabolism
MH  - Female
MH  - Fibronectins/*metabolism
MH  - Humans
MH  - Laryngeal Neoplasms/*metabolism/pathology
MH  - Larynx/metabolism/pathology
MH  - Lymphatic Metastasis
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Staging
MH  - Prognosis
EDAT- 2010/04/03 06:00
MHDA- 2011/06/28 06:00
CRDT- 2010/04/03 06:00
PHST- 2010/04/03 06:00 [entrez]
PHST- 2010/04/03 06:00 [pubmed]
PHST- 2011/06/28 06:00 [medline]
PST - ppublish
SO  - Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2009 Dec;23(24):1130-3.