PMID- 20359119
OWN - NLM
STAT- MEDLINE
DCOM- 20110609
LR  - 20171116
IS  - 2096-7993 (Print)
IS  - 2096-7993 (Linking)
VI  - 23
IP  - 21
DP  - 2009 Nov
TI  - [Expression of RAGE in laryngeal squamous cell carcinoma and clinical 
      significance].
PG  - 985-8
AB  - OBJECTIVE: To study the expression and clinical significance of receptor for 
      advanced glycation end products (RAGE) in laryngeal squamous cell carcinoma 
      (LSCC). METHOD: immunohistochemical staining was used to detect the expressions 
      of RAGE protein and semiquantitative method of reverse transcriptase polymerase 
      chain reaction (RT-PCR) was used to analyze the expression level of RAGE mRNA in 
      LSCC tissues and laryngeal normal tissues of 37 cases, respectively. RESULT: The 
      mRNA and protein expression of RAGE was significantly higher in LSCC than that in 
      normal laryngeal tissues (P < 0.05), correlated with differentiation (P < 0.01), 
      but not with tumor stage and location (P > 0.05). CONCLUSION: The expression 
      levels of RAGE were significantly higher in LSCC than these in laryngeal normal 
      tissues, RAGE is involved in differentiation of LSCC.
FAU - Zhang, Huiping
AU  - Zhang H
AD  - Department of Otolaryngology Head and Neck Surgery, First Affiliated Hospital of 
      Fujian Medical University, Fuzhou, 350005, Chin.
FAU - Zhang, Rong
AU  - Zhang R
FAU - Shangguan, Hanjing
AU  - Shangguan H
LA  - chi
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
JT  - Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical 
      otorhinolaryngology, head, and neck surgery
JID - 101303164
RN  - 0 (Receptor for Advanced Glycation End Products)
RN  - 0 (Receptors, Immunologic)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Carcinoma, Squamous Cell/*metabolism/pathology
MH  - Humans
MH  - Laryngeal Neoplasms/*metabolism/pathology
MH  - Lymphatic Metastasis
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Staging
MH  - Receptor for Advanced Glycation End Products
MH  - Receptors, Immunologic/*metabolism
MH  - Reverse Transcriptase Polymerase Chain Reaction
EDAT- 2010/04/03 06:00
MHDA- 2011/06/10 06:00
CRDT- 2010/04/03 06:00
PHST- 2010/04/03 06:00 [entrez]
PHST- 2010/04/03 06:00 [pubmed]
PHST- 2011/06/10 06:00 [medline]
PST - ppublish
SO  - Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2009 Nov;23(21):985-8.