PMID- 20360680
OWN - NLM
STAT- MEDLINE
DCOM- 20100614
LR  - 20211203
IS  - 1460-2075 (Electronic)
IS  - 0261-4189 (Print)
IS  - 0261-4189 (Linking)
VI  - 29
IP  - 10
DP  - 2010 May 19
TI  - Pericentrosomal targeting of Rab6 secretory vesicles by Bicaudal-D-related 
      protein 1 (BICDR-1) regulates neuritogenesis.
PG  - 1637-51
LID - 10.1038/emboj.2010.51 [doi]
AB  - Membrane and secretory trafficking are essential for proper neuronal development. 
      However, the molecular mechanisms that organize secretory trafficking are poorly 
      understood. Here, we identify Bicaudal-D-related protein 1 (BICDR-1) as an 
      effector of the small GTPase Rab6 and key component of the molecular machinery 
      that controls secretory vesicle transport in developing neurons. BICDR-1 
      interacts with kinesin motor Kif1C, the dynein/dynactin retrograde motor complex, 
      regulates the pericentrosomal localization of Rab6-positive secretory vesicles 
      and is required for neural development in zebrafish. BICDR-1 expression is high 
      during early neuronal development and strongly declines during neurite outgrowth. 
      In young neurons, BICDR-1 accumulates Rab6 secretory vesicles around the 
      centrosome, restricts anterograde secretory transport and inhibits 
      neuritogenesis. Later during development, BICDR-1 expression is strongly reduced, 
      which permits anterograde secretory transport required for neurite outgrowth. 
      These results indicate an important role for BICDR-1 as temporal regulator of 
      secretory trafficking during the early phase of neuronal differentiation.
FAU - Schlager, Max A
AU  - Schlager MA
AD  - Department of Neuroscience, Erasmus Medical Center, Rotterdam, The Netherlands.
FAU - Kapitein, Lukas C
AU  - Kapitein LC
FAU - Grigoriev, Ilya
AU  - Grigoriev I
FAU - Burzynski, Grzegorz M
AU  - Burzynski GM
FAU - Wulf, Phebe S
AU  - Wulf PS
FAU - Keijzer, Nanda
AU  - Keijzer N
FAU - de Graaff, Esther
AU  - de Graaff E
FAU - Fukuda, Mitsunori
AU  - Fukuda M
FAU - Shepherd, Iain T
AU  - Shepherd IT
FAU - Akhmanova, Anna
AU  - Akhmanova A
FAU - Hoogenraad, Casper C
AU  - Hoogenraad CC
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100401
PL  - England
TA  - EMBO J
JT  - The EMBO journal
JID - 8208664
RN  - 0 (Adaptor Proteins, Signal Transducing)
RN  - 0 (Adaptor Proteins, Vesicular Transport)
RN  - 0 (BICD1 protein, human)
RN  - 0 (Bicdl1 protein, mouse)
RN  - 0 (Cytoskeletal Proteins)
RN  - 0 (KIF1C protein, human)
RN  - 0 (Rab6 protein)
RN  - EC 3.6.4.4 (Kinesins)
RN  - EC 3.6.5.2 (rab GTP-Binding Proteins)
SB  - IM
CIN - EMBO J. 2010 May 19;29(10):1625-6. PMID: 20485297
MH  - Adaptor Proteins, Signal Transducing/*metabolism
MH  - Adaptor Proteins, Vesicular Transport/*metabolism
MH  - Animals
MH  - Brain/metabolism
MH  - COS Cells
MH  - Cell Differentiation
MH  - Cell Membrane/metabolism
MH  - Centrosome/*ultrastructure
MH  - Chlorocebus aethiops
MH  - Cytoskeletal Proteins/*metabolism
MH  - Humans
MH  - Kidney/metabolism
MH  - Kinesins/chemistry
MH  - Models, Biological
MH  - Neurons/metabolism/*pathology
MH  - Zebrafish
MH  - rab GTP-Binding Proteins/*metabolism
PMC - PMC2876961
COIS- The authors declare that they have no conflict of interest.
EDAT- 2010/04/03 06:00
MHDA- 2010/06/15 06:00
PMCR- 2010/04/01
CRDT- 2010/04/03 06:00
PHST- 2009/09/10 00:00 [received]
PHST- 2010/03/01 00:00 [accepted]
PHST- 2010/04/03 06:00 [entrez]
PHST- 2010/04/03 06:00 [pubmed]
PHST- 2010/06/15 06:00 [medline]
PHST- 2010/04/01 00:00 [pmc-release]
AID - emboj201051 [pii]
AID - 10.1038/emboj.2010.51 [doi]
PST - ppublish
SO  - EMBO J. 2010 May 19;29(10):1637-51. doi: 10.1038/emboj.2010.51. Epub 2010 Apr 1.