PMID- 20361354
OWN - NLM
STAT- MEDLINE
DCOM- 20100820
LR  - 20211020
IS  - 1573-6903 (Electronic)
IS  - 0364-3190 (Linking)
VI  - 35
IP  - 7
DP  - 2010 Jul
TI  - Chronic administration of cyclosporine A changes expression of BDNF and TrkB in 
      rat hippocampus and midbrain.
PG  - 1098-104
LID - 10.1007/s11064-010-0160-0 [doi]
AB  - Neurotrophins, including the brain-derived neurotrophic factor (BDNF), are 
      essential for regulating neuronal differentiation in developing brains. BDNF and 
      its receptor tyrosine kinase receptor B (TrkB) are involved in neuronal 
      signaling, survival and plasticity. Cyclosporine A (CsA) is a potent 
      immunosuppressive agent which prevents allograft rejection in organ 
      transplantation and various immunological diseases. We investigated whether 
      chronic administration of CsA decreases BDNF gene expression in rats, and the 
      influence of CsA on mRNA levels of TrkB receptors was also examined. For 30 days 
      of CsA (10 mg/kg/day) administration, the expression of BDNF and TrkB mRNA was 
      significantly decreased in the hippocampus and midbrain, but there was no 
      significant difference in the cortex. CsA (0, 1, 5 10, 15 ug/ml) down-regulated 
      BDNF and TrkB gene expression through cultured SH-SY5Y cells, as did all-trans 
      retinoic acid (ATRA), and there was no effect on cell viability. These 
      experimental results indicate that suppression of the BDNF and TrkB mRNA, protein 
      level of BDNF expression in the hippocampus and midbrain may be related to 
      altered behavior observed following chronic administration of CsA. A common 
      mechanism of adverse effects of CsA induced depressive symptoms may involve 
      neurotoxicity mediated by down-regulation of brain BDNF and TrkB.
FAU - Chen, Chien-Chih
AU  - Chen CC
AD  - Department of Psychiatry, Chang Gung Memorial Hospital-Kaohsiung Medical Center, 
      Chang Gung University College of Medicine, 123 Ta-Pei Rd, Niao-Sung, Kaohsiung, 
      83305, Taiwan, ROC.
FAU - Hsu, Li-Wen
AU  - Hsu LW
FAU - Huang, Li-Tung
AU  - Huang LT
FAU - Huang, Tiao-Lai
AU  - Huang TL
LA  - eng
PT  - Journal Article
DEP - 20100402
PL  - United States
TA  - Neurochem Res
JT  - Neurochemical research
JID - 7613461
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Immunosuppressive Agents)
RN  - 0 (RNA, Messenger)
RN  - 83HN0GTJ6D (Cyclosporine)
RN  - EC 2.7.10.1 (Receptor, trkB)
SB  - IM
MH  - Animals
MH  - Body Weight/drug effects
MH  - Brain-Derived Neurotrophic Factor/*biosynthesis/genetics
MH  - Cell Line, Tumor
MH  - Cyclosporine/*adverse effects
MH  - Down-Regulation
MH  - Hippocampus/*drug effects/metabolism
MH  - Humans
MH  - Immunosuppressive Agents/*adverse effects
MH  - Mesencephalon/*drug effects/metabolism
MH  - RNA, Messenger/biosynthesis
MH  - Rats
MH  - Receptor, trkB/*biosynthesis/genetics
EDAT- 2010/04/03 06:00
MHDA- 2010/08/21 06:00
CRDT- 2010/04/03 06:00
PHST- 2010/03/22 00:00 [accepted]
PHST- 2010/04/03 06:00 [entrez]
PHST- 2010/04/03 06:00 [pubmed]
PHST- 2010/08/21 06:00 [medline]
AID - 10.1007/s11064-010-0160-0 [doi]
PST - ppublish
SO  - Neurochem Res. 2010 Jul;35(7):1098-104. doi: 10.1007/s11064-010-0160-0. Epub 2010 
      Apr 2.