PMID- 20362279
OWN - NLM
STAT- MEDLINE
DCOM- 20100825
LR  - 20220331
IS  - 1090-2163 (Electronic)
IS  - 0008-8749 (Linking)
VI  - 263
IP  - 1
DP  - 2010
TI  - Inhibiting effects of total saponins of panax ginseng on immune maturation of 
      dendritic cells induced by oxidized-low density lipoprotein.
PG  - 99-104
LID - 10.1016/j.cellimm.2010.03.004 [doi]
AB  - Total saponins of panax ginseng (TSPG) are the major active components in panax 
      ginseng. Dendritic cells (DCs) play an active role in the immunological processes 
      related to atherosclerosis. The purpose of this study was to determine the effect 
      and possible mechanisms of TSPG on the maturation and immune function of DCs. 
      Compared with those untreated, the DCs pre-treated with TSPG and then induced by 
      oxidized-LDL exhibited a significantly lower expression of the 
      maturation-associated markers of CD40, CD86, HLA-DR, and CD1a, together with an 
      increased endocytosic function as well as decreased secretions of cytokine. 
      However, silencing the expression of PPARgamma in DCs, the inhibitory effect of 
      TSPG on the maturation DCs was significantly reduced. In conclusion, TSPG could 
      inhibit the maturation of DCs induced by oxidized-LDL which suggests beneficial 
      effects on atherosclerosis and this effect was partly dependent on the PPARgamma 
      pathway at least.
CI  - Copyright 2010 Elsevier Inc. All rights reserved.
FAU - Su, Wei
AU  - Su W
AD  - Institute of Cardiovascular Diseases, Zhongshan Hospital of Fudan University, 
      Shanghai 200032, China.
FAU - Sun, Ai-Jun
AU  - Sun AJ
FAU - Xu, Dan-Ling
AU  - Xu DL
FAU - Zhang, Hong-Qi
AU  - Zhang HQ
FAU - Yang, Lin
AU  - Yang L
FAU - Yuan, Ling-Yan
AU  - Yuan LY
FAU - Jia, Jian-Guo
AU  - Jia JG
FAU - Zou, Yun-Zeng
AU  - Zou YZ
FAU - Wu, Yi-Ling
AU  - Wu YL
FAU - Wang, Ke-Qiang
AU  - Wang KQ
FAU - Ge, Jun-Bo
AU  - Ge JB
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100311
PL  - Netherlands
TA  - Cell Immunol
JT  - Cellular immunology
JID - 1246405
RN  - 0 (Antigens, CD)
RN  - 0 (Antigens, Differentiation)
RN  - 0 (Cytokines)
RN  - 0 (HLA Antigens)
RN  - 0 (Lipoproteins, LDL)
RN  - 0 (PPAR gamma)
RN  - 0 (RNA, Small Interfering)
RN  - 0 (Saponins)
RN  - 0 (oxidized low density lipoprotein)
SB  - IM
MH  - Antigens, CD/biosynthesis
MH  - Antigens, Differentiation/biosynthesis/genetics
MH  - Atherosclerosis/*immunology
MH  - Cell Differentiation/drug effects/genetics
MH  - Cytokines/biosynthesis/genetics/metabolism
MH  - Dendritic Cells/*drug effects/immunology/metabolism/pathology
MH  - Down-Regulation
MH  - Endocytosis/drug effects
MH  - HLA Antigens/biosynthesis/genetics
MH  - Humans
MH  - Lipoproteins, LDL/metabolism
MH  - PPAR gamma/genetics/*metabolism
MH  - Panax/*chemistry
MH  - RNA, Small Interfering/genetics
MH  - Saponins/*pharmacology
EDAT- 2010/04/07 06:00
MHDA- 2010/08/26 06:00
CRDT- 2010/04/06 06:00
PHST- 2010/01/10 00:00 [received]
PHST- 2010/03/03 00:00 [accepted]
PHST- 2010/04/06 06:00 [entrez]
PHST- 2010/04/07 06:00 [pubmed]
PHST- 2010/08/26 06:00 [medline]
AID - S0008-8749(10)00066-3 [pii]
AID - 10.1016/j.cellimm.2010.03.004 [doi]
PST - ppublish
SO  - Cell Immunol. 2010;263(1):99-104. doi: 10.1016/j.cellimm.2010.03.004. Epub 2010 
      Mar 11.