PMID- 20363155
OWN - NLM
STAT- MEDLINE
DCOM- 20101116
LR  - 20100712
IS  - 1557-3117 (Electronic)
IS  - 1053-2498 (Linking)
VI  - 29
IP  - 7
DP  - 2010 Jul
TI  - In praise of ventricular assist devices-mechanical bridge to virtual crossmatch 
      for the sensitized patient.
PG  - 728-30
LID - 10.1016/j.healun.2010.02.006 [doi]
AB  - Human leukocyte antigen (HLA) sensitization is a common problem in patients being 
      assessed for organ transplantation. Two overarching principles that must be 
      adhered to when evaluating approaches to sensitized patients are: (1) ensuring 
      equitable access for potential recipients to transplantable organs; and (2) 
      maintaining optimal long-term patient and graft outcomes post-transplant. 
      Approaches increasingly used to manage sensitized heart transplant candidates are 
      crossmatching (virtual [VXM], based on comparison of donor HLA to recipient 
      antibody specificities, or prospective real-time [XM]) to avoid donor-specific 
      antibodies, or desensitization to reduce the amount of antibodies that are 
      present. We propose that the best strategy for management of highly sensitized 
      patients awaiting heart transplantation is combining mechanical circulatory 
      support as a bridge to a (-) VXM or XM together with adoption of a national 
      prioritized sharing algorithm for highly sensitized patients.
FAU - Ross, Heather
AU  - Ross H
AD  - Toronto General Hospital, University Health Network, Toronto, Ontario, Canada.
FAU - Tinckam, Kathryn
AU  - Tinckam K
FAU - Rao, Vivek
AU  - Rao V
FAU - West, Lori J
AU  - West LJ
LA  - eng
PT  - Editorial
DEP - 20100402
PL  - United States
TA  - J Heart Lung Transplant
JT  - The Journal of heart and lung transplantation : the official publication of the 
      International Society for Heart Transplantation
JID - 9102703
RN  - 0 (Antibodies)
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Antibodies/blood
MH  - HLA Antigens/immunology
MH  - Heart Diseases/blood/*therapy
MH  - Heart Transplantation/*immunology
MH  - *Heart-Assist Devices
MH  - *Histocompatibility Testing
MH  - Humans
MH  - *Immunization
MH  - Time Factors
EDAT- 2010/04/07 06:00
MHDA- 2010/11/17 06:00
CRDT- 2010/04/06 06:00
PHST- 2010/01/02 00:00 [received]
PHST- 2010/01/29 00:00 [revised]
PHST- 2010/02/04 00:00 [accepted]
PHST- 2010/04/06 06:00 [entrez]
PHST- 2010/04/07 06:00 [pubmed]
PHST- 2010/11/17 06:00 [medline]
AID - S1053-2498(10)00078-1 [pii]
AID - 10.1016/j.healun.2010.02.006 [doi]
PST - ppublish
SO  - J Heart Lung Transplant. 2010 Jul;29(7):728-30. doi: 
      10.1016/j.healun.2010.02.006. Epub 2010 Apr 2.