PMID- 20363876 OWN - NLM STAT- MEDLINE DCOM- 20101222 LR - 20211020 IS - 1944-9917 (Electronic) IS - 0888-8809 (Print) IS - 0888-8809 (Linking) VI - 24 IP - 9 DP - 2010 Sep TI - Minireview: Estrogen receptor-beta: mechanistic insights from recent studies. PG - 1703-14 LID - 10.1210/me.2009-0288 [doi] AB - The discovery of estrogen receptor-beta (ERbeta) in 1996 stimulated great interest in the physiological roles and molecular mechanisms of ERbeta action. We now know that ERbeta plays a major role in mediating estrogen action in several tissues and organ systems, including the ovary, cardiovascular system, brain, and the immune system, and that ERbeta and ERalpha generally play distinct physiological roles in the body. Although significant progress has been made toward understanding the molecular mechanisms of ERbeta action, particularly in vitro, there remains a large gap in our understanding of the mechanisms by which ERbeta elicits its biological functions in a true physiological context. FAU - Deroo, Bonnie J AU - Deroo BJ AD - The University of Western Ontario, Room A4-144, Children's Health Research Institute, 800 Commissioners Road East, London, Ontario, Canada N6C 2V5. bderoo2@uwo.ca FAU - Buensuceso, Adrian V AU - Buensuceso AV LA - eng PT - Journal Article PT - Review DEP - 20100402 PL - United States TA - Mol Endocrinol JT - Molecular endocrinology (Baltimore, Md.) JID - 8801431 RN - 0 (Estrogen Receptor beta) RN - 0 (Ligands) SB - IM MH - Animals MH - Estrogen Receptor beta/*metabolism MH - Humans MH - Ligands MH - Receptor Cross-Talk MH - Signal Transduction PMC - PMC5417404 EDAT- 2010/04/07 06:00 MHDA- 2010/12/24 06:00 PMCR- 2011/09/01 CRDT- 2010/04/06 06:00 PHST- 2010/04/06 06:00 [entrez] PHST- 2010/04/07 06:00 [pubmed] PHST- 2010/12/24 06:00 [medline] PHST- 2011/09/01 00:00 [pmc-release] AID - me.2009-0288 [pii] AID - 10.1210/me.2009-0288 [doi] PST - ppublish SO - Mol Endocrinol. 2010 Sep;24(9):1703-14. doi: 10.1210/me.2009-0288. Epub 2010 Apr 2.