PMID- 20364597
OWN - NLM
STAT- MEDLINE
DCOM- 20120706
LR  - 20131121
IS  - 1000-8020 (Print)
IS  - 1000-8020 (Linking)
VI  - 39
IP  - 1
DP  - 2010 Jan
TI  - [Effects of perinatal exposure to sulphamethazine on the thyroid gland function 
      of SD rats].
PG  - 83-5
AB  - OBJECTIVE: To study the effect of perinatal exposure sulphamethazine on the 
      function of thyroid gland of SD rats. METHODS: Dams were given sulphamethazine 0, 
      50, 100 and 200 mg/(kg x d) respectively from gestational day (GD) 7 to 
      postpartum day (P) 21. The sections of thyroid gland of pups 20 days after birth 
      were stained by hematoxylin-eosin, and the expression of proliferating cell 
      nuclear antigen (PCNA) were observed by immunohistochemistry staining. RESULTS: 
      Compare with control, thyroid gland showed proliferation of follicular epithelium 
      in each experimental group, and the numbers of PCNA positive cells in thyroid 
      gland significantly higher than that of control (P < 0.05). CONCLUSION: Perinatal 
      exposure to sulphamethazine may affect the function of thyroid gland of 
      offspring.
FAU - Wang, Jintao
AU  - Wang J
AD  - Department of Environmental Health, West China School of Public Health, China. 
      wangjt620@126.com
FAU - Sun, Ding
AU  - Sun D
FAU - Qiu, Yunliang
AU  - Qiu Y
FAU - Zhang, Hao
AU  - Zhang H
FAU - Wu, Desheng
AU  - Wu D
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - China
TA  - Wei Sheng Yan Jiu
JT  - Wei sheng yan jiu = Journal of hygiene research
JID - 9426367
RN  - 0 (Anti-Infective Agents)
RN  - 0 (Proliferating Cell Nuclear Antigen)
RN  - 48U51W007F (Sulfamethazine)
SB  - IM
MH  - Animals
MH  - Anti-Infective Agents/toxicity
MH  - Female
MH  - Male
MH  - *Maternal Exposure
MH  - Pregnancy
MH  - *Prenatal Exposure Delayed Effects
MH  - Proliferating Cell Nuclear Antigen/metabolism
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Sulfamethazine/*toxicity
MH  - Thyroid Gland/metabolism/pathology/*physiology
EDAT- 2010/04/07 06:00
MHDA- 2012/07/07 06:00
CRDT- 2010/04/07 06:00
PHST- 2010/04/07 06:00 [entrez]
PHST- 2010/04/07 06:00 [pubmed]
PHST- 2012/07/07 06:00 [medline]
PST - ppublish
SO  - Wei Sheng Yan Jiu. 2010 Jan;39(1):83-5.