PMID- 2036477
OWN - NLM
STAT- MEDLINE
DCOM- 19910703
LR  - 20190815
IS  - 0006-3223 (Print)
IS  - 0006-3223 (Linking)
VI  - 29
IP  - 4
DP  - 1991 Feb 15
TI  - Abnormalities of lithium transport across the erythrocyte membrane in depression 
      and schizophrenia.
PG  - 340-6
AB  - Three mechanisms of lithium transport across erythrocyte membrane [lithium-sodium 
      countertransport (LSC), lithium-potassium cotransport (LPC), and passive lithium 
      diffusion (PLD)] were estimated in 27 acutely schizophrenic patients, 27 acutely 
      depressed affective patients and in 18 control subjects. The activities of all 
      mechanisms studied were significantly lower in both schizophrenic and depressed 
      patients compared with controls. Analysis by gender showed that in control 
      subjects, mean values of erythrocyte LSC and LPC were significantly higher in 
      males compared with females. The decrease of LSC and LPC in depression and LSC in 
      schizophrenia compared with control subjects was observed only in male patients 
      but not in female ones. The results obtained suggest that lithium transport 
      abnormalities during acute psychotic episodes are not specific to affective 
      patients where lithium exerts its therapeutic action, but are also observed in 
      schizophrenia. These abnormalities are more evident in male patients.
FAU - Rybakowski, J K
AU  - Rybakowski JK
AD  - Department of Psychiatry, Medical Academy, Bydgoszcz, Poland.
FAU - Lehmann, W
AU  - Lehmann W
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Biol Psychiatry
JT  - Biological psychiatry
JID - 0213264
RN  - 9FN79X2M3F (Lithium)
SB  - IM
MH  - Acute Disease
MH  - Bipolar Disorder/*blood/psychology
MH  - Depressive Disorder/*blood/psychology
MH  - Erythrocyte Membrane/*metabolism
MH  - Humans
MH  - Lithium/*pharmacokinetics
MH  - Psychiatric Status Rating Scales
MH  - Schizophrenia/*blood
MH  - Schizophrenic Psychology
EDAT- 1991/02/15 00:00
MHDA- 1991/02/15 00:01
CRDT- 1991/02/15 00:00
PHST- 1991/02/15 00:00 [pubmed]
PHST- 1991/02/15 00:01 [medline]
PHST- 1991/02/15 00:00 [entrez]
AID - 0006-3223(91)90219-C [pii]
AID - 10.1016/0006-3223(91)90219-c [doi]
PST - ppublish
SO  - Biol Psychiatry. 1991 Feb 15;29(4):340-6. doi: 10.1016/0006-3223(91)90219-c.