PMID- 20368089
OWN - NLM
STAT- MEDLINE
DCOM- 20100629
LR  - 20220318
IS  - 2542-5641 (Electronic)
IS  - 0366-6999 (Linking)
VI  - 123
IP  - 6
DP  - 2010 Mar 20
TI  - Neuronal firing in the ventrolateral thalamus of patients with Parkinson's 
      disease differs from that with essential tremor.
PG  - 695-701
AB  - BACKGROUND: Although thalamotomy could dramatically improve both parkinsonian 
      resting tremor and essential tremor (ET), the mechanisms are obviously different. 
      This study aimed to investigate the neuronal activities in the ventrolateral 
      thalamus of Parkinson's disease (PD) and ET. METHODS: Thirty-six patients (PD: 
      20, ET: 16) were studied. Microelectrode recordings in the ventral oral posterior 
      (Vop) and the ventral intermediate nucleus (Vim) of thalamus was performed on 
      these patients who underwent thalamotomy. Electromyography (EMG) was recorded 
      simultaneously on the contralateral limbs to surgery. Single unit analysis and 
      the interspike intervals (ISIs) were measured for each neuronal type. ISI 
      histogram and auto-correlograms were constructed to estimate the pattern of 
      neuronal firing. Mann-Whitney test and Kruskal-Wallis (K-W) test were used to 
      compare the mean spontaneous firing rate (MSFR) of neurons of PD and ET patients. 
      RESULTS: Three hundred and twenty-three neurons were obtained from 20 PD 
      trajectories, including 151 (46.7%) tremor related neuronal activity, 74 neurons 
      (22.9%) with tonic firing, and 98 (30.4%) neurons with irregular discharge. One 
      hundred and eighty-seven neurons were identified from 16 ET trajectories 
      including 46 (24.6%) tremor-related neuronal activity, 77 (41.2%) neurons with 
      tonic firing, and 64 neurons (34.2%) with irregular discharge. The analysis of 
      MSFR of neurons with tonic firing was 26.7 (3.4 - 68.3) Hz (n = 74) and that of 
      neurons with irregular discharge (n = 98) was 13.9 (3.0 - 58.1) Hz in PD; whereas 
      MSFR of neurons with tonic firing (n = 77) was 48.8 (19.0 - 135.5) Hz and that of 
      neurons with irregular discharge (n = 64) was 26.3 (8.7 - 84.7) Hz in ET. There 
      were significant differences in the MSFR of two types of neuron for PD and ET 
      (K-W test, both P < 0.05). Significant differences in the MSFR of neuron were 
      also obtained from Vop and Vim of PD and ET (16.3 Hz vs. 34.8 Hz, 28.0 Hz vs. 
      49.9 Hz) (K-W test, both P < 0.05), respectively. CONCLUSION: In consistent with 
      recent findings, the decreased MSFR of neurons observed in the Vop is likely to 
      be involved in PD whereas the increased MSFR of neurons seen in the Vim may be a 
      cause of ET.
FAU - Chen, Hai
AU  - Chen H
AD  - Beijing Institute of Functional Neurosurgery, Department of Neurology, Xuanwu 
      Hospital, Capital Medical University, Key Laboratory of Neurodegenerative 
      Diseases, Ministry of Education, Beijing 100053, China.
FAU - Zhuang, Ping
AU  - Zhuang P
FAU - Miao, Su-hua
AU  - Miao SH
FAU - Yuan, Gao
AU  - Yuan G
FAU - Zhang, Yu-qing
AU  - Zhang YQ
FAU - Li, Jian-yu
AU  - Li JY
FAU - Li, Yong-jie
AU  - Li YJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Chin Med J (Engl)
JT  - Chinese medical journal
JID - 7513795
SB  - IM
MH  - Essential Tremor/*physiopathology
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Neurons/*physiology
MH  - Parkinson Disease/*physiopathology
MH  - Retrospective Studies
MH  - Ventral Thalamic Nuclei/*physiopathology
EDAT- 2010/04/07 06:00
MHDA- 2010/06/30 06:00
CRDT- 2010/04/07 06:00
PHST- 2010/04/07 06:00 [entrez]
PHST- 2010/04/07 06:00 [pubmed]
PHST- 2010/06/30 06:00 [medline]
PST - ppublish
SO  - Chin Med J (Engl). 2010 Mar 20;123(6):695-701.