PMID- 20368210
OWN - NLM
STAT- MEDLINE
DCOM- 20100706
LR  - 20221207
IS  - 1752-8984 (Electronic)
IS  - 1479-1641 (Linking)
VI  - 6
IP  - 3
DP  - 2009 Jul
TI  - Raised natriuretic peptides, big-endothelin-1 and improved beta-cell function in 
      type 2 diabetic males with hyperuricaemia.
PG  - 190-3
LID - 10.1177/1479164109336689 [doi]
AB  - Urate, a naturally-occurring antioxidant, is a marker/factor for cardiovascular 
      disease. Hyperuricaemia is associated with IR, MetS and endothelial dysfunction. 
      We characterised the associations between neurohormones, uricaemia, and glucose 
      homeostasis in type 2 diabetes mellitus (T2DM) males. Cross-sectional; 705 T2DM 
      males divided into two groups: uric acid < 7.0 mg/dl (normouricaemic; n=476) 
      versus uric acid >or= 7.0 mg/dl (hyperuricaemic; n=229). HOMA beta-cell function 
      (B), insulin sensitivity (S), hyperbolic product (BxS), and (BxS) loss rate were 
      determined alongside neurohormones (Nt-proANP, BNP, Big ET-1 and UII). Mean age 
      and diabetes duration were not different between groups. Hyperuricaemics had more 
      macroangiopathy, total/central adiposity, IR, hypertension, dyslipidemia and MetS 
      prevalence. Nt-proANP and BNP levels were more than twice as high in 
      hyperuricaemics, whereas Big ET-1 and UII were higher by 46% and 14%, 
      respectively. HOMA (BxS) was higher in hyperuricaemics: 31 (16)% vs. 26 (18)% 
      (p=0.0004). BxS loss rate was faster in normouricaemics: 1.36 (0.54)% vs. 1.20 
      (0.43)%/year(-1) (p<0.0001 ). The proportion with HbA(1C) < 7.0% was 39% 
      (normouricaemics) vs. 49% (hyperuricaemics; p=0.0091). In T2DM males, 
      hyperuricaemia is associated with raised neurohormones together with better 
      beta-cell indices. Urate's dual properties may translate into beneficial (glucose 
      homeostasis) and detrimental (raised neurohormones) effects.
FAU - Hermans, Michel P
AU  - Hermans MP
AD  - Endocrinology and Nutrition Unit, Cliniques Universitaires St-Luc, Brussels, 
      Belgium. michel.hermans@diab.ucl.ac.be
FAU - Ahn, Sylvie A
AU  - Ahn SA
FAU - Rousseau, Michel F
AU  - Rousseau MF
LA  - eng
PT  - Journal Article
PL  - England
TA  - Diab Vasc Dis Res
JT  - Diabetes & vascular disease research
JID - 101234011
RN  - 0 (Biomarkers)
RN  - 0 (Blood Glucose)
RN  - 0 (Endothelin-1)
RN  - 0 (Glycated Hemoglobin A)
RN  - 0 (Insulin)
RN  - 0 (hemoglobin A1c protein, human)
RN  - 114471-18-0 (Natriuretic Peptide, Brain)
RN  - 268B43MJ25 (Uric Acid)
RN  - 85637-73-6 (Atrial Natriuretic Factor)
SB  - IM
MH  - Aged
MH  - Atrial Natriuretic Factor/*blood
MH  - Biomarkers/blood
MH  - Blood Glucose/metabolism
MH  - Cross-Sectional Studies
MH  - Diabetes Mellitus, Type 2/*blood/complications/physiopathology
MH  - Endothelin-1/*blood
MH  - Glycated Hemoglobin/metabolism
MH  - Humans
MH  - Hyperuricemia/*blood/complications/physiopathology
MH  - Insulin/blood
MH  - Insulin-Secreting Cells/*metabolism
MH  - Male
MH  - Metabolic Syndrome/*blood/complications/physiopathology
MH  - Middle Aged
MH  - Natriuretic Peptide, Brain/*blood
MH  - Up-Regulation
MH  - Uric Acid/blood
EDAT- 2010/04/07 06:00
MHDA- 2010/07/07 06:00
CRDT- 2010/04/07 06:00
PHST- 2010/04/07 06:00 [entrez]
PHST- 2010/04/07 06:00 [pubmed]
PHST- 2010/07/07 06:00 [medline]
AID - 6/3/190 [pii]
AID - 10.1177/1479164109336689 [doi]
PST - ppublish
SO  - Diab Vasc Dis Res. 2009 Jul;6(3):190-3. doi: 10.1177/1479164109336689.