PMID- 20368224
OWN - NLM
STAT- MEDLINE
DCOM- 20100706
LR  - 20221207
IS  - 1752-8984 (Electronic)
IS  - 1479-1641 (Linking)
VI  - 6
IP  - 4
DP  - 2009 Oct
TI  - Plasma monocyte chemoattractant protein-1 as risk marker in type 2 diabetes 
      mellitus and coronary artery disease in North Indians.
PG  - 288-90
LID - 10.1177/1479164109346364 [doi]
AB  - The chemokine monocyte chemoattractant protein-1 (MCP-1) is implicated in chronic 
      inflammation, insulin resistance and atherosclerosis. The present study was 
      designed to explore the relation of plasma levels of MCP-1 to disease pathology 
      in type 2 diabetes and coronary artery disease (CAD) patients. Fasting plasma 
      venous samples were taken from 162 subjects divided into four groups: Patients 
      with type 2 diabetes mellitus and CAD (n=41), type 2 diabetes patients without 
      CAD (n=50), CAD patients with no history of diabetes (n=41) and healthy controls 
      (n=30). Coronary risk factors such as body mass index, percentage body fat, 
      waist/hip ratio, blood pressure and physical activity were measured using 
      standard procedures. Plasma MCP-1 was quantitatively estimated by sandwich 
      enzyme-linked immunoabsorbent assay (ELISA). Significant differences were 
      observed for MCP-1 levels, percent body fat, body mass index, waist/hip ratio, 
      systolic and diastolic blood pressure amongst the groups. MCP-1 concentration was 
      significantly correlated with diabetes duration (p<0.001), body mass index 
      (p<0.01), waist/hip ratio (p<0.01), systolic blood pressure (p<0.01), percentage 
      body fat (p<0.01) and physical activity level (p<0.001). MCP-1 might serve as a 
      marker for CAD, and its association with CAD is mainly driven by traditional 
      coronary risk factors.
FAU - Harsimran, Kaur
AU  - Harsimran K
AD  - Department of Human Genetics, Guru Nanak Dev University, Amritsar, Punjab, India.
FAU - Singh, Arora Ajinder Pal
AU  - Singh AA
FAU - Guruvinder, Singh
AU  - Guruvinder S
FAU - Sharda, Sidhu
AU  - Sharda S
FAU - Vasudha, Sambyal
AU  - Vasudha S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Diab Vasc Dis Res
JT  - Diabetes & vascular disease research
JID - 101234011
RN  - 0 (Biomarkers)
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
SB  - IM
MH  - Adiposity/ethnology
MH  - Adult
MH  - Aged
MH  - *Asian People
MH  - Biomarkers/blood
MH  - Blood Pressure
MH  - Body Mass Index
MH  - Chemokine CCL2/*blood
MH  - Coronary Artery Disease/*blood/ethnology/etiology/physiopathology
MH  - Diabetes Mellitus, Type 2/*blood/complications/ethnology/physiopathology
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Humans
MH  - India
MH  - Linear Models
MH  - Middle Aged
MH  - Risk Assessment
MH  - Risk Factors
MH  - Waist-Hip Ratio
EDAT- 2010/04/07 06:00
MHDA- 2010/07/07 06:00
CRDT- 2010/04/07 06:00
PHST- 2010/04/07 06:00 [entrez]
PHST- 2010/04/07 06:00 [pubmed]
PHST- 2010/07/07 06:00 [medline]
AID - 6/4/288 [pii]
AID - 10.1177/1479164109346364 [doi]
PST - ppublish
SO  - Diab Vasc Dis Res. 2009 Oct;6(4):288-90. doi: 10.1177/1479164109346364.