PMID- 20370448
OWN - NLM
STAT- MEDLINE
DCOM- 20100720
LR  - 20161125
IS  - 1525-6049 (Electronic)
IS  - 0886-022X (Linking)
VI  - 32
IP  - 3
DP  - 2010 Jan
TI  - Parameters of oxidative stress and echocardiographic indexes in patients on 
      dialysis therapy.
PG  - 328-34
LID - 10.3109/08860221003606299 [doi]
AB  - AIM: Quantity of oxidative stress (OS) is enhanced in every stage of chronic 
      renal failure (CRF). OS and its effects on echocardiographic indexes in patients 
      on hemodialysis (HD) and continuous ambulatory peritoneal dialysis (CAPD) were 
      evaluated. MATERIALS AND METHODS: Thirty-nine patients on CAPD, 32 patients on 
      HD, and 30 healthy individuals with similar demographic features were included. 
      Patients with diabetes mellitus and chronic inflammatory diseases were excluded. 
      Blood samples were collected to examine hematological and biochemical parameters 
      and levels of malonyldialdehyde (MDA), glutathione peroxidase (GSH-px), and 
      superoxide dismutase (SOD) after a 12-hour fasting period in the middle of 
      dialysis week. OS parameters were compared with ejection fraction (EF), 
      interventricular septum diameter (IVSd), left ventricular posterior wall diameter 
      (LVPWd), and left atrium diameter (LAd) determined in M-mod echocardiographic 
      examination. RESULTS: No significant difference was observed between MDA and 
      GSH-px levels of patients and control group; however, SOD levels of patients 
      group were significantly lower (p<0.0001). SOD levels of patients on HD were 
      lower than that of patients on CAPD (p=0.039). Negative correlation was detected 
      between MDA and EF (r=-0.380, p=0.001); SOD has negative correlation with 
      systolic blood pressure (r=-0.265, p=0.011), diastolic blood pressure (r=-0.230, 
      p=0.028), phosphorus (r=-0.327, p=0.001), intact parathyroid hormone (iPTH) 
      (r=-0.259, p=0.013), C-reactive protein (CRP) (r=-0.235, p=0.024), fibrinogen 
      (r=-0.342, p=0.001), and total cholesterol (r=-0.249, p=0.017); and positive 
      correlation with hemoglobin (r=0.414, p<0.001) and albumin (r=0.367, p<0.001). 
      MDA was independently related with age (beta=-0.258, p=0.035), male gender 
      (beta=-0.312, p=0.004), and EF (beta=-0.461, p<0.001). No correlation was 
      determined between antioxidants and cardiac indexes. CONCLUSION: SOD levels 
      decreased significantly especially in patients on HD, and it was observed that 
      lower levels of SOD would lead to OS in patients on HD and CAPD when compared to 
      healthy individuals; MDA levels were independently influenced from EF.
FAU - Kayabasi, Hasan
AU  - Kayabasi H
AD  - Department of Nephrology, Faculty of Medicine, Dicle University, and Department 
      of Internal Medicine, Silvan State Hospital, Diyarbakir, Turkey. 
      drkayabasi@yahoo.com
FAU - Sit, Dede
AU  - Sit D
FAU - Atay, A Engin
AU  - Atay AE
FAU - Yilmaz, Zulfukar
AU  - Yilmaz Z
FAU - Kadiroglu, Ali Kemal
AU  - Kadiroglu AK
FAU - Yilmaz, M Emin
AU  - Yilmaz ME
LA  - eng
PT  - Journal Article
PL  - England
TA  - Ren Fail
JT  - Renal failure
JID - 8701128
RN  - 4Y8F71G49Q (Malondialdehyde)
RN  - EC 1.11.1.9 (Glutathione Peroxidase)
RN  - EC 1.15.1.1 (Superoxide Dismutase)
SB  - IM
MH  - *Echocardiography
MH  - Female
MH  - Glutathione Peroxidase/blood
MH  - Humans
MH  - Hypertrophy, Left Ventricular/complications/*diagnostic imaging
MH  - Kidney Failure, Chronic/complications/*metabolism/therapy
MH  - Male
MH  - Malondialdehyde/blood
MH  - *Oxidative Stress
MH  - *Peritoneal Dialysis, Continuous Ambulatory
MH  - *Renal Dialysis
MH  - Superoxide Dismutase/blood
EDAT- 2010/04/08 06:00
MHDA- 2010/07/21 06:00
CRDT- 2010/04/08 06:00
PHST- 2010/04/08 06:00 [entrez]
PHST- 2010/04/08 06:00 [pubmed]
PHST- 2010/07/21 06:00 [medline]
AID - 10.3109/08860221003606299 [doi]
PST - ppublish
SO  - Ren Fail. 2010 Jan;32(3):328-34. doi: 10.3109/08860221003606299.