PMID- 20370493
OWN - NLM
STAT- MEDLINE
DCOM- 20100810
LR  - 20100513
IS  - 1557-8577 (Electronic)
IS  - 1549-1684 (Linking)
VI  - 13
IP  - 2-3
DP  - 2010 Apr-Jun
TI  - Progression of atherosclerotic lesions in the arteries and related gene 
      expression: protective effect of phytonutrients.
PG  - 242-5
LID - 10.1089/rej.2009.0949 [doi]
AB  - We investigated the effect of the phytocompound Denshici-to-Chiusei (DTS) on the 
      atherogenesis in apolipoprotein E(-/-)/low-density lipoprotein receptor(-/-) 
      (apoE(-/-)/LDL receptor(-/-)) mice (E0). E0 mice were fed for 16 weeks with: (1) 
      placebo or (2) 25 mg or (3) 50 mg of DTS/day. Aortic lesions were reduced by 38% 
      (p < 0.01) in mice fed 50 mg/day, whereas peritoneal macrophages after both 
      dosages had a 45%-60% lower (p < 0.01) capacity to oxidize LDL and to degrade it. 
      This was associated with reduced LDL-associated lipoperoxides and a 22% 
      inhibition (p < 0.05) in LDL aggregation. Tumor necrosis factor-alpha (TNF-alpha) 
      expression and immunoreactivity in the aortic media increased five-fold, but this 
      was significantly mitigated by DTS (50 mg > 25 mg) (p < 0.05). DTS significantly 
      attenuated inflammatory mechanisms preceding atherogenesis with reduced LDL 
      susceptibility to oxidation-aggregation.
FAU - Marotta, Francesco
AU  - Marotta F
AD  - ReGenera Research Group, Milano, Italy.
FAU - Harada, Masatoshi
AU  - Harada M
FAU - Minelli, Emilio
AU  - Minelli E
FAU - Yadav, Hariom
AU  - Yadav H
FAU - Polimeni, Ascanio
AU  - Polimeni A
FAU - Lorenzetti, Alao
AU  - Lorenzetti A
FAU - Locorotondo, Nicola
AU  - Locorotondo N
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Rejuvenation Res
JT  - Rejuvenation research
JID - 101213381
RN  - 0 (Apolipoproteins E)
RN  - 0 (Denshici-to-Chiusei)
RN  - 0 (Plant Preparations)
RN  - 0 (Receptors, LDL)
SB  - IM
MH  - Animals
MH  - Apolipoproteins E/genetics
MH  - Arteries/drug effects/metabolism/pathology
MH  - Atherosclerosis/*genetics/*pathology/*prevention & control
MH  - Cells, Cultured
MH  - Cytoprotection/drug effects/genetics
MH  - Disease Models, Animal
MH  - Disease Progression
MH  - Drug Evaluation, Preclinical
MH  - Eucommiaceae
MH  - *Food
MH  - Gene Expression/drug effects
MH  - Macrophages, Peritoneal/drug effects/metabolism/pathology
MH  - Male
MH  - Mice
MH  - Mice, Knockout
MH  - Panax
MH  - Panax notoginseng/chemistry
MH  - Phytotherapy
MH  - Plant Preparations/pharmacology/*therapeutic use
MH  - Receptors, LDL/genetics
EDAT- 2010/04/08 06:00
MHDA- 2010/08/11 06:00
CRDT- 2010/04/08 06:00
PHST- 2010/04/08 06:00 [entrez]
PHST- 2010/04/08 06:00 [pubmed]
PHST- 2010/08/11 06:00 [medline]
AID - 10.1089/rej.2009.0949 [doi]
PST - ppublish
SO  - Rejuvenation Res. 2010 Apr-Jun;13(2-3):242-5. doi: 10.1089/rej.2009.0949.