PMID- 20373512
OWN - NLM
STAT- MEDLINE
DCOM- 20100818
LR  - 20161021
IS  - 1934-8258 (Electronic)
IS  - 1934-8258 (Linking)
VI  - Chapter 10
DP  - 2010 Apr
TI  - Molecular analysis of genetic markers for non-Hodgkin lymphomas.
PG  - Unit 10.14.1-25
LID - 10.1002/0471142905.hg1014s65 [doi]
AB  - Molecular analysis complements the clinical and histopathologic tools used to 
      diagnose and subclassify hematologic malignancies. The presence of clonal 
      antigen-receptor gene rearrangements can help to confirm the diagnosis of a B or 
      T cell lymphoma and can serve as a fingerprint of that neoplasm to be used in 
      identifying concurrent disease at disparate sites or recurrence at future time 
      points. Certain lymphoid malignancies harbor a characteristic chromosomal 
      translocation, a finding that may have significant implications for an 
      individual's prognosis or response to therapy. The polymerase chain reaction 
      (PCR) is typically used to detect antigen-receptor gene rearrangements as well as 
      specific translocations that can be supplemented by fluorescence in situ 
      hybridization (FISH) and karyotype analysis.
CI  - (c) 2010 by John Wiley & Sons, Inc.
FAU - Sholl, Lynette M
AU  - Sholl LM
AD  - Brigham and Women's Hospital, Boston, Massachusetts, USA.
FAU - Longtine, Janina
AU  - Longtine J
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Curr Protoc Hum Genet
JT  - Current protocols in human genetics
JID - 101287858
RN  - 0 (Genetic Markers)
RN  - 0 (Immunoglobulin Heavy Chains)
RN  - 0 (Receptors, Antigen, T-Cell, gamma-delta)
SB  - IM
MH  - Gene Rearrangement/*genetics
MH  - Genetic Markers/*genetics
MH  - Humans
MH  - Immunoglobulin Heavy Chains/genetics
MH  - In Situ Hybridization, Fluorescence/methods
MH  - Karyotyping/methods
MH  - Lymphoma, Non-Hodgkin/*genetics
MH  - Polymerase Chain Reaction/methods
MH  - Receptors, Antigen, T-Cell, gamma-delta/genetics
MH  - Translocation, Genetic/*genetics
EDAT- 2010/04/08 06:00
MHDA- 2010/08/19 06:00
CRDT- 2010/04/08 06:00
PHST- 2010/04/08 06:00 [entrez]
PHST- 2010/04/08 06:00 [pubmed]
PHST- 2010/08/19 06:00 [medline]
AID - 10.1002/0471142905.hg1014s65 [doi]
PST - ppublish
SO  - Curr Protoc Hum Genet. 2010 Apr;Chapter 10:Unit 10.14.1-25. doi: 
      10.1002/0471142905.hg1014s65.