PMID- 20374368
OWN - NLM
STAT- MEDLINE
DCOM- 20100713
LR  - 20191210
IS  - 1756-185X (Electronic)
IS  - 1756-1841 (Linking)
VI  - 12
IP  - 4
DP  - 2009 Dec
TI  - Estimation of monocyte-chemoattractantprotein-1 (Mcp-1) level in patients with 
      lupus nephritis.
PG  - 311-8
LID - 10.1111/j.1756-185X.2009.01429.x [doi]
AB  - AIM: To evaluate the use of non-invasive estimation of CP-1 in urine as a good 
      indicator for lupus nephritis activity. METHODS: The study was conducted on 30 
      patients with systemic lupus erythematosus (SLE) (group I): 15 of these patients 
      were selected without renal involvement (group I [A]), and the other 15 were 
      selected with evidence of renal involvement (group I [B]). Further 10 age- and 
      sex-matched healthy subjects were taken as a control group (group II). The SLE 
      disease activity index (SLEDAI) was applied. Laboratory investigations done for 
      the studied group of patients included: renal function tests (antinuclear 
      antibody) titer, (anti-double-stranded DNA) titer, and monocyte chemotactic 
      protein 1 (MCP-1) level in serum and urine samples. RESULTS: Serum MCP-1 was 
      significantly higher in SLE patients with nephritis than in the control group, 
      while no significant difference was found between SLE patients without nephritis 
      and the control group. Urinary MCP-1 in patients with active lupus nephritis (LN) 
      were significantly higher than both patients with inactive LN and control the 
      group. Urinary MCP-1 in SLE patients with nephritis was significantly higher than 
      both group I (A) and group II. Urinary MCP-1 correlated positively with 
      proteinuria, and negatively with creatinine clearance and hemoglobin; thus, 
      urinary MCP-1 correlates with the severity of nephritis. CONCLUSION: Urinary and 
      not serum MCP-1 is a useful invasive technique for the assessment of renal 
      disease activity in patients with LN.
FAU - Alzawawy, Ashraf
AU  - Alzawawy A
AD  - Alexandria Faculty of Medicine-Internal Medicine, Rheumatology Unit, Alexandria, 
      Egypt. ashrafzawawy@hotmail.com
FAU - Zohary, Magdy
AU  - Zohary M
FAU - Ablordiny, Magdy
AU  - Ablordiny M
FAU - Eldalie, Mona
AU  - Eldalie M
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
PL  - England
TA  - Int J Rheum Dis
JT  - International journal of rheumatic diseases
JID - 101474930
RN  - 0 (Antibodies, Antinuclear)
RN  - 0 (Biomarkers)
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
RN  - 9007-49-2 (DNA)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Age of Onset
MH  - Antibodies, Antinuclear/analysis
MH  - Biomarkers/blood/urine
MH  - Chemokine CCL2/blood/*urine
MH  - DNA/immunology
MH  - Female
MH  - Humans
MH  - Kidney Function Tests
MH  - Lupus Nephritis/blood/physiopathology/*urine
MH  - Male
MH  - Middle Aged
MH  - Predictive Value of Tests
MH  - Severity of Illness Index
MH  - Young Adult
EDAT- 2010/04/09 06:00
MHDA- 2010/07/14 06:00
CRDT- 2010/04/09 06:00
PHST- 2010/04/09 06:00 [entrez]
PHST- 2010/04/09 06:00 [pubmed]
PHST- 2010/07/14 06:00 [medline]
AID - APL1429 [pii]
AID - 10.1111/j.1756-185X.2009.01429.x [doi]
PST - ppublish
SO  - Int J Rheum Dis. 2009 Dec;12(4):311-8. doi: 10.1111/j.1756-185X.2009.01429.x.