PMID- 20374388
OWN - NLM
STAT- MEDLINE
DCOM- 20100706
LR  - 20151119
IS  - 1756-185X (Electronic)
IS  - 1756-1841 (Linking)
VI  - 13
IP  - 1
DP  - 2010 Feb 1
TI  - Fetuin-A and interleukin-18 levels in ankylosing spondylitis.
PG  - 75-81
LID - 10.1111/j.1756-185X.2009.01448.x [doi]
AB  - AIM: Interleukin-18 (IL-18) and fetuin-A have been implicated in atherosclerosis. 
      Preliminary evidence suggests that ankylosing spondylitis (AS) is associated with 
      an increased risk of atherosclerosis. The aim of the present study was to 
      investigate possible abnormalities in IL-18 and fetuin-A levels in AS. METHODS: 
      Subjects without established cardiovascular (CV) risk factors were studied. 
      Fasting glucose, serum lipids, high sensitive C-reactive protein (hsCRP), 
      erythrocyte sedimentation rate, IL-18 and fetuin-A were assessed. Patients were 
      also evaluated with the Bath Ankylosing Spondylitis Metrology Index, Bath 
      Ankylosing Spondylitis Functional Index, and the Bath Ankylosing Spondylitis 
      Disease Activity Index. RESULTS: Fourty-five patients with AS (37.4 +/- 9.7 
      years; 35M/10F) and 29 controls (35.5 +/- 11.1 years; 21M/8F) were studied. 
      Fetuin-A levels were significantly higher in AS patients compared to controls 
      (1023.5 +/- 171.6 vs. 856.9 +/- 207.9 microg/mL, P < 0.001). IL-18 levels were 
      also higher in the AS group but the difference was not significant (184 +/- 186 
      vs. 140 +/- 115, P = 0.1). Significant but weak correlations were found between 
      fetuin-A, IL-18, hsCRP, low density lipoprotein cholesterol, and triglyceride 
      levels (P < 0.05; r = 0.4, 0.3, 0.2, and 0.3 respectively). Comparison of 
      subjects with respect to the treatment type, disease activity and history of 
      peripheral arthritis yielded no difference regarding fetuin-A and IL-18 between 
      groups. CONCLUSION: Fetuin-A and IL-18 levels seem to be increased in AS patients 
      regardless of disease activity and treatment type.
FAU - Sari, Ismail
AU  - Sari I
AD  - Department of Internal Medicine, Izmir Bozyaka Training and Research Hospital, 
      Izmir, Turkey. ismailsari35@gmail.com
FAU - Kebapcilar, Levent
AU  - Kebapcilar L
FAU - Taylan, Ali
AU  - Taylan A
FAU - Bilgir, Oktay
AU  - Bilgir O
FAU - Kozaci, Didem L
AU  - Kozaci DL
FAU - Yildiz, Yasar
AU  - Yildiz Y
FAU - Yuksel, Arif
AU  - Yuksel A
FAU - Gunay, Necati
AU  - Gunay N
FAU - Akkoc, Nurullah
AU  - Akkoc N
LA  - eng
PT  - Journal Article
PL  - England
TA  - Int J Rheum Dis
JT  - International journal of rheumatic diseases
JID - 101474930
RN  - 0 (AHSG protein, human)
RN  - 0 (Biomarkers)
RN  - 0 (Blood Proteins)
RN  - 0 (Cholesterol, LDL)
RN  - 0 (Interleukin-18)
RN  - 0 (Triglycerides)
RN  - 0 (alpha-2-HS-Glycoprotein)
RN  - 9007-41-4 (C-Reactive Protein)
SB  - IM
MH  - Adult
MH  - Biomarkers/blood
MH  - Blood Proteins/*analysis
MH  - C-Reactive Protein/analysis
MH  - Case-Control Studies
MH  - Cholesterol, LDL/blood
MH  - Female
MH  - Humans
MH  - Interleukin-18/*blood
MH  - Male
MH  - Middle Aged
MH  - Registries
MH  - Spondylitis, Ankylosing/*immunology/therapy
MH  - Triglycerides/blood
MH  - Turkey
MH  - Up-Regulation
MH  - alpha-2-HS-Glycoprotein
EDAT- 2010/04/09 06:00
MHDA- 2010/07/07 06:00
CRDT- 2010/04/09 06:00
PHST- 2010/04/09 06:00 [entrez]
PHST- 2010/04/09 06:00 [pubmed]
PHST- 2010/07/07 06:00 [medline]
AID - APL1448 [pii]
AID - 10.1111/j.1756-185X.2009.01448.x [doi]
PST - ppublish
SO  - Int J Rheum Dis. 2010 Feb 1;13(1):75-81. doi: 10.1111/j.1756-185X.2009.01448.x.