PMID- 20374397
OWN - NLM
STAT- MEDLINE
DCOM- 20100923
LR  - 20211020
IS  - 1532-5415 (Electronic)
IS  - 0002-8614 (Print)
IS  - 0002-8614 (Linking)
VI  - 58
IP  - 5
DP  - 2010 May
TI  - Maximum daily 6 minutes of activity: an index of functional capacity derived from 
      actigraphy and its application to older adults with heart failure.
PG  - 931-6
LID - 10.1111/j.1532-5415.2010.02805.x [doi]
AB  - OBJECTIVES: To compare the correlation between the maximum 6 minutes of daily 
      activity (M6min) and standard measures of functional capacity in older adults 
      with heart failure (HF) with that in younger subjects and its prognostic utility. 
      DESIGN: Prospective, cohort study. SETTING: Tertiary care, academic HF center. 
      PARTICIPANTS: Sixty, ambulatory, adults, New York Heart Association (NYHA) Class 
      I to III, stratified into young (50.9 +/- 9.4) and older cohorts (76.8 +/- 8.0). 
      MEASUREMENTS: Correlation between M6min and measures of functional capacity 
      (6-minute walk test; 6MWT) and peak oxygen consumption (VO(2)) according to 
      cardiopulmonary exercise testing in a subset of subjects. Survival analysis was 
      employed to evaluate the association between M6min and adverse events. RESULTS: 
      Adherence to actigraphy was high (90%) and did not differ according to age. The 
      correlation between M6min and 6MWT was higher in subjects aged 65 and older than 
      in those younger than 65 (correlation coefficient (r=0.702, P<.001 vs r=0.490, 
      P=.002). M6min was also significantly associated with peak VO(2) (r=0.612, 
      P=.006). During the study, 26 events occurred (2 deaths, 10 hospitalizations, 8 
      emergency department visits, and 6 intercurrent illnesses). The M6min was 
      significantly associated with subsequent events (hazard ratio=2.728, 95% 
      confidence interval=1.10-6.77, P=.03), independent of age, sex, ejection 
      fraction, NYHA class, brain natriuretic peptide, and 6MWT. CONCLUSION: The high 
      adherence to actigraphy and association with standard measures of functional 
      capacity and independent association with subsequent morbid events suggest that 
      it may be useful for monitoring older adults with HF.
FAU - Howell, Jason
AU  - Howell J
AD  - Healthcare Innovation and Technology Laboratory, New York, New York, USA.
FAU - Strong, B Michelle
AU  - Strong BM
FAU - Weisenberg, Jenny
AU  - Weisenberg J
FAU - Kakade, Anagha
AU  - Kakade A
FAU - Gao, Qian
AU  - Gao Q
FAU - Cuddihy, Paul
AU  - Cuddihy P
FAU - Delisle, Susan
AU  - Delisle S
FAU - Kachnowski, Stan
AU  - Kachnowski S
FAU - Maurer, Mathew S
AU  - Maurer MS
LA  - eng
GR  - K24 AG036778/AG/NIA NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
DEP - 20100330
PL  - United States
TA  - J Am Geriatr Soc
JT  - Journal of the American Geriatrics Society
JID - 7503062
SB  - IM
MH  - Actigraphy
MH  - Aged
MH  - Cohort Studies
MH  - Female
MH  - Heart Failure/mortality/*physiopathology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Motor Activity/*physiology
MH  - Prognosis
MH  - Prospective Studies
MH  - Time Factors
PMC - PMC3779057
MID - NIHMS509359
EDAT- 2010/04/09 06:00
MHDA- 2010/09/24 06:00
PMCR- 2013/09/20
CRDT- 2010/04/09 06:00
PHST- 2010/04/09 06:00 [entrez]
PHST- 2010/04/09 06:00 [pubmed]
PHST- 2010/09/24 06:00 [medline]
PHST- 2013/09/20 00:00 [pmc-release]
AID - JGS2805 [pii]
AID - 10.1111/j.1532-5415.2010.02805.x [doi]
PST - ppublish
SO  - J Am Geriatr Soc. 2010 May;58(5):931-6. doi: 10.1111/j.1532-5415.2010.02805.x. 
      Epub 2010 Mar 30.