PMID- 20374620
OWN - NLM
STAT- MEDLINE
DCOM- 20100805
LR  - 20211020
IS  - 1477-7819 (Electronic)
IS  - 1477-7819 (Linking)
VI  - 8
DP  - 2010 Apr 7
TI  - Intraductal papillary mucinous neoplasm of the pancreas (IPMN): 
      clinico-pathological correlations and surgical indications.
PG  - 25
LID - 10.1186/1477-7819-8-25 [doi]
AB  - BACKGROUND: Intraductal papillary mucinous neoplasms (IPMNs) are increasingly 
      recognized entities, whose management remains sometimes controversial, due to the 
      high rate of benign lesions and on the other side to the good survival after 
      resection of malignant ones. METHODS: Retrospective analysis of a prospectively 
      collected Western series of IPMN. RESULTS: Forty cases of IPMN were analysed 
      (1992-2007). Most patients were symptomatic (72.5%); cholangio-MRI had the best 
      diagnostic accuracy both for the tumour nature (83.3%) and for the presence of 
      malignancy (57.1%). ERCP was done in 8 cases (20%), and the results were poor. 
      Thirteen patients were treated by pancreatic resection and 27 were maintained in 
      follow-up. Total pancreatectomy was performed in 46% of the cases; in situ and 
      invasive carcinoma were recognized in 15.4% and 38.4% of the cases, respectively. 
      The mean follow-up was 42 months (range 12-72). One only patients with nodal 
      metastases died 16 months after the operation for disease progression, while 
      91.6% of the operated patients are disease free. Out of the 27 not resected 
      patients, 2 out of 4 presenting a lesion at high risk for malignancy died, while 
      the remaining are in good conditions and disease free, with a mean follow-up of 
      31 months. CONCLUSION: Therapeutic indication for IPMNs is mainly based upon 
      radiological evaluation of the risk of malignancy. While the main duct tumours 
      should be resected, preserving whenever possible a portion of the gland, the 
      secondary ducts tumours may be maintained under observation, in absence of 
      radiological elements of suspicion such as size larger than 3 cm, or a wall 
      greater than 3 mm or nodules or papillae in the context of the cyst.
FAU - Baiocchi, Gian Luca
AU  - Baiocchi GL
AD  - Department of Medical and Surgical Sciences, Surgical Clinic, Brescia University, 
      P,le Spedali Civili, 1, 25123 Brescia, Italy. baiocchi@med.unibs.it
FAU - Portolani, Nazario
AU  - Portolani N
FAU - Missale, Guido
AU  - Missale G
FAU - Baronchelli, Carla
AU  - Baronchelli C
FAU - Gheza, Federico
AU  - Gheza F
FAU - Cantu, Massimiliano
AU  - Cantu M
FAU - Grazioli, Luigi
AU  - Grazioli L
FAU - Giulini, Stefano M
AU  - Giulini SM
LA  - eng
PT  - Journal Article
DEP - 20100407
PL  - England
TA  - World J Surg Oncol
JT  - World journal of surgical oncology
JID - 101170544
SB  - IM
MH  - Adenocarcinoma, Mucinous/*pathology/surgery
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Carcinoma, Pancreatic Ductal/*pathology/surgery
MH  - Carcinoma, Papillary/*pathology/surgery
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Lymphatic Metastasis
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Recurrence, Local/pathology/surgery
MH  - Neoplasm Staging
MH  - *Pancreatectomy
MH  - Pancreatic Neoplasms/*pathology/surgery
MH  - Prospective Studies
MH  - Retrospective Studies
MH  - Risk Factors
MH  - Survival Rate
MH  - Treatment Outcome
PMC - PMC2858722
EDAT- 2010/04/09 06:00
MHDA- 2010/08/06 06:00
PMCR- 2010/04/07
CRDT- 2010/04/09 06:00
PHST- 2009/12/21 00:00 [received]
PHST- 2010/04/07 00:00 [accepted]
PHST- 2010/04/09 06:00 [entrez]
PHST- 2010/04/09 06:00 [pubmed]
PHST- 2010/08/06 06:00 [medline]
PHST- 2010/04/07 00:00 [pmc-release]
AID - 1477-7819-8-25 [pii]
AID - 10.1186/1477-7819-8-25 [doi]
PST - epublish
SO  - World J Surg Oncol. 2010 Apr 7;8:25. doi: 10.1186/1477-7819-8-25.