PMID- 20374627
OWN - NLM
STAT- MEDLINE
DCOM- 20100706
LR  - 20240117
IS  - 1532-429X (Electronic)
IS  - 1097-6647 (Print)
IS  - 1097-6647 (Linking)
VI  - 12
IP  - 1
DP  - 2010 Apr 7
TI  - Quantitative analysis of late gadolinium enhancement in hypertrophic 
      cardiomyopathy.
PG  - 21
LID - 10.1186/1532-429X-12-21 [doi]
AB  - BACKGROUND: Cardiovascular magnetic resonance (CMR) with the late gadolinium 
      enhancement (LGE) technique allows the detection of myocardial fibrosis in 
      Hypertrophic cardiomyopathy (HCM). The aim of this study was to compare different 
      methods of automatic quantification of LGE in HCM patients. METHODS: Forty HCM 
      patients (mean age 48 y, 30 males) and 20 normal subjects (mean age 38 y, 16 
      males) underwent CMR, and we compared 3 methods of quantification of LGE: 1) in 
      the SD2 method a region of interest (ROI) was placed within the normal myocardium 
      and enhanced myocardium was considered as having signal intensity >2 SD above the 
      mean of ROI; 2) in the SD6 method enhanced myocardium was defined with a cut-off 
      of 6 SD above mean of ROI; 3) in the RC method a ROI was placed in the background 
      of image, a Rayleigh curve was created using the SD of that ROI and used as ideal 
      curve of distribution of signal intensity of a perfectly nulled myocardium. The 
      maximal signal intensity found in the Rayleigh curve was used as cut-off for 
      enhanced myocardium. Parametric images depicting non enhanced and enhanced 
      myocardium was created using each method. Three investigators assigned a score to 
      each method by the comparison of the original LGE image to the respective 
      parametric map generated. RESULTS: Patients with HCM had lower concordance 
      between the measured curve of distribution of signal intensity and the Rayleigh 
      curve than controls (63.7 +/- 12.3% vs 92.2 +/- 2.3%, p < 0.0001).A cut off of 
      concordance < 82.9% had a 97.1% sensitivity and 92.3% specificity to distinguish 
      HCM from controls. The RC method had higher score than the other methods. The 
      average extent of enhanced myocardium measured by SD6 and Rayleigh curve method 
      was not significant different but SD6 method showed underestimation of 
      enhancement in 12% and overestimation in 5% of patients with HCM. CONCLUSIONS: 
      Quantification of fibrosis in LGE images with a cut-off derived from the Rayleigh 
      curve is more accurate than using a fixed cut-off.
FAU - Aquaro, Giovanni Donato
AU  - Aquaro GD
AD  - MRI laboratory, Foundation G, Monasterio Regione Toscana/CNR, Pisa, Italy. 
      aquaro@ifc.cnr.it
FAU - Positano, Vincenzo
AU  - Positano V
FAU - Pingitore, Alessandro
AU  - Pingitore A
FAU - Strata, Elisabetta
AU  - Strata E
FAU - Di Bella, Gianluca
AU  - Di Bella G
FAU - Formisano, Francesco
AU  - Formisano F
FAU - Spirito, P
AU  - Spirito P
FAU - Lombardi, Massimo
AU  - Lombardi M
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20100407
PL  - England
TA  - J Cardiovasc Magn Reson
JT  - Journal of cardiovascular magnetic resonance : official journal of the Society 
      for Cardiovascular Magnetic Resonance
JID - 9815616
RN  - 0 (Contrast Media)
RN  - K2I13DR72L (Gadolinium DTPA)
SB  - IM
MH  - Adult
MH  - *Algorithms
MH  - Cardiomyopathy, Hypertrophic/*diagnosis
MH  - Case-Control Studies
MH  - *Contrast Media
MH  - Female
MH  - Fibrosis
MH  - *Gadolinium DTPA
MH  - Humans
MH  - *Image Interpretation, Computer-Assisted
MH  - Magnetic Resonance Imaging, Cine/*methods
MH  - Male
MH  - Middle Aged
MH  - Myocardium/*pathology
MH  - Observer Variation
MH  - Predictive Value of Tests
MH  - Reproducibility of Results
MH  - Sensitivity and Specificity
PMC - PMC2867984
EDAT- 2010/04/09 06:00
MHDA- 2010/07/07 06:00
PMCR- 2010/04/07
CRDT- 2010/04/09 06:00
PHST- 2009/10/08 00:00 [received]
PHST- 2010/04/07 00:00 [accepted]
PHST- 2010/04/09 06:00 [entrez]
PHST- 2010/04/09 06:00 [pubmed]
PHST- 2010/07/07 06:00 [medline]
PHST- 2010/04/07 00:00 [pmc-release]
AID - S1097-6647(23)01301-7 [pii]
AID - 1532-429X-12-21 [pii]
AID - 10.1186/1532-429X-12-21 [doi]
PST - epublish
SO  - J Cardiovasc Magn Reson. 2010 Apr 7;12(1):21. doi: 10.1186/1532-429X-12-21.